rs11224052 - LINC02714 - LINC02697

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study on amyotrophic lateral sclerosis in the Taiwanese Han population. - Biomarkers in medicine (2017) · Chen CJ, Chen CM, Pai TW, Chang HT, Hwang CS · PubMed 26580837

  Identification of mutations in patients with amyotrophic lateral sclerosis (ALS) in a genome-wide association study can reveal possible biomarkers of such a rapidly progressive and fatal neurodegenerative disease. It was observed that significant single nucleotide polymorphisms vary when the tested population changes from one ethnic group to another. To identify new loci associated with ALS susceptibility in the Taiwanese Han population, we performed a genome-wide association study on 94 patients with sporadic ALS and 376 matched controls. We uncovered two new susceptibility loci at 13q14.3 (rs2785946) and 11q25 (rs11224052). In addition, we analyzed the functions of all the associated genes among 54 significant single nucleotide polymorphisms using Gene Ontology annotations, and the resul

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