Expressive

rs11223444 (OPCML): Genetic Variant Overview

Key takeaways

  • None of the four provided studies explicitly reports an association for rs11223444 in the OPCML gene.
  • The supplied studies cover large-scale GWAS in Korean, East Asian, and European populations for dozens of traits.
  • Sample sizes in the reviewed studies range from approximately 153,950 to 628,000 participants.
  • No lifestyle considerations are on file for this variant from the provided sources.

Key takeaways

  • None of the four provided studies explicitly reports an association for rs11223444 in the OPCML gene.
  • The supplied studies cover large-scale genome-wide association analyses in Korean, East Asian, and European populations for traits including metabolic biomarkers, obesity-related traits, asthma subtypes, and muscular strength.
  • Sample sizes in the reviewed studies range from approximately 153,950 to 628,000 participants.
  • No lifestyle considerations are on file for this variant from the provided sources.

What the research says The four studies supplied for this entry - covering 36 quantitative traits in 153,950 Korean participants, 220 phenotypes in up to 628,000 participants across East Asian and European biobanks, shared genetic components between obesity-related traits and asthma subtypes in 457,822 European-ancestry individuals, and grip strength in 334,925 UK Biobank participants - do not explicitly report an association for rs11223444 in any of their provided text. Across these large-scale analyses, which together identified thousands of genome-wide significant loci using methods such as linear mixed models and cross-population meta-analysis at genome-wide significance thresholds (P < 5 x 10-8), rs11223444 in the OPCML region does not appear as a reported finding.

Reported associations

  • No associations for rs11223444 are explicitly reported in the provided studies.

Evidence quality The four provided studies are large, well-powered GWAS with sample sizes ranging from approximately 153,950 individuals in the Korean Cancer Prevention Study-II Biobank to a combined 628,000 in cross-population meta-analysis including UK Biobank, BioBank Japan, and FinnGen. These studies applied rigorous statistical controls including linear mixed models, linkage disequilibrium score regression, and multiple population replication. Across them, hundreds to thousands of genome-wide significant loci were identified. However, none of the supplied study texts explicitly report findings for rs11223444, so no evidence quality assessment for this specific variant can be made from the provided sources.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11223444?

rs11223444 is a single-nucleotide polymorphism (a single-letter difference in the DNA code) located in or near the OPCML gene. The studies reviewed for this entry do not explicitly report associations for this variant.

What is the OPCML gene?

The four studies provided for this entry do not describe the function of the OPCML gene.

Is rs11223444 linked to any diseases or health traits?

The four large-scale GWAS studies reviewed for this entry do not explicitly report an association between rs11223444 and any disease or measurable health trait.

Has rs11223444 been studied in diverse populations?

The provided studies include large cohorts from Korean, East Asian, and European populations, but none explicitly identifies rs11223444 as an associated variant in their reported results.