rs11218708 - RNU6-592P - GLULP3

Magnitude 4.5 · 1 study on file

Reported associations

• Association Study and Fine-Mapping Major Histocompatibility Complex Analysis of Pemphigus Vulgaris in a Han Chinese Population. - The Journal of investigative dermatology (2019) · Gao J, Zhu C, Zhang Y, Sheng Y, Yang F, Wang W, Qian W, Chen S, Zhu Q, Zuo X, Tang H, Tang X, Li Y, Cheng H, Zhou F, Liu S, Chen G, Zheng X, Zhu Z, Wang Z, Yang S, Luo X, Ye D, Zhang X, Sun L · PubMed 29857070

  To identify possible additional genetic susceptibility loci for pemphigus vulgaris (PV), we performed a genome-wide association study of 240 PV patients and 1,031 control individuals, and we selected the top single nucleotide polymorphisms for replication in independent samples, with 252 patient samples and 1,852 control samples. We identified rs11218708 (P = 3.1 × 10 , odds ratio = 1.54) at chromosome locus 11q24.1 as significantly associated with PV. A fine-mapping analysis of PV risk in the major histocompatibility complex region showed three independent variants predisposed to PV using stepwise analysis: HLA-DRB1*14:04 (P = 2.47 × 10 , odds ratio = 6.28), rs7454108 at the TAP2 gene (P = 2.78 × 10 , odds ratio = 3.25), and rs1051336 at the HLA-DRA gene (P = 3.06 × 10 , od

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