rs11217223 (LINC02713/CNTN5): Childhood Obesity GWAS

Key takeaways

• rs11217223 sits in a genomic region spanning LINC02713 and CNTN5, flagged in a genome-wide scan of childhood obesity traits in Hispanic children.
• The study that identified it enrolled 815 children from 263 Hispanic families in Houston, Texas, and genotyped 1.1 million SNPs.
• Evidence comes from a single study in a pediatric Hispanic population; independent replication is not reported in the provided materials.
• The full range of traits examined included anthropometry, body composition, metabolites, hormones, inflammation, diet, energy expenditure, and physical activity.

What the research says rs11217223 in the LINC02713 / CNTN5 region was identified in the VIVA LA FAMILIA Study, a genome-wide association study (GWAS) of 815 Hispanic children from 263 families conducted in Houston, Texas between 2000 and 2005 PMID 23840893. The study used Illumina Infinium technology to genotype 1.1 million single nucleotide polymorphisms (SNPs, meaning one-letter changes in the DNA sequence) and examined an unusually broad set of obesity-related traits, including anthropometry (body measurements), body composition, growth, metabolites, hormones, inflammation markers, diet, energy expenditure, substrate utilization (how the body burns fuel), and physical activity PMID 23840893. The provided study materials do not specify which trait or traits this locus was most strongly associated with in that analysis.

Reported associations

• Childhood obesity-related traits (Hispanic pediatric population): This locus was identified in a GWAS examining multiple obesity-related traits in 815 Hispanic children ascertained through obese probands (children with a BMI above the 95th percentile); the specific trait driving the association is not detailed in the provided study excerpt PMID 23840893.

Evidence quality The evidence for this locus rests on a single study of 815 Hispanic children, a sample size that is modest by current GWAS standards, where large-scale studies commonly involve tens to hundreds of thousands of participants PMID 23840893. The VIVA LA FAMILIA cohort was ascertained on obese probands, meaning families were recruited specifically because at least one child had a BMI above the 95th percentile, which may inflate some associations relative to a general population sample. No independent replication of rs11217223 is reported in the provided materials, and precise effect sizes or p-values for this variant are not available in the provided study text. The evidence should be considered preliminary.

Lifestyle considerations No lifestyle considerations on file for this variant.