rs11206670 (LINC01755): Thyroid eQTL Variant
Key takeaways
- rs11206670 is located near LINC01755, a long intergenic non-coding RNA gene that does not produce protein
- GTEx data from 953 donors consistently shows this variant reducing LINC01755 expression in thyroid tissue
- A neighboring gene (ENSG00000297128) also shows reduced expression in thyroid tissue linked to the same variant
- This variant was catalogued in the VA Million Veteran Program, a GWAS of 635,969 participants across diverse US populations
- No lifestyle factors or drug responses have been specifically linked to this variant in the available evidence
Key takeaways
- rs11206670 is located near LINC01755, a long intergenic non-coding RNA gene that does not produce protein
- GTEx data from 953 donors consistently shows this variant reducing LINC01755 expression in thyroid tissue
- A neighboring gene (ENSG00000297128) also shows reduced expression in thyroid tissue linked to the same variant
- This variant was catalogued in the VA Million Veteran Program, a GWAS of 635,969 participants across diverse US populations
- No lifestyle factors or drug responses have been specifically linked to this variant in the available evidence
What the research says rs11206670 is a variant at the LINC01755 locus ("LINC" stands for long intergenic non-coding RNA, meaning the gene lies between protein-coding genes and does not itself produce a protein). It was identified in the VA Million Veteran Program (MVP), a large-scale genome-wide association study of 635,969 US veterans across four diverse population groups that catalogued over 26,049 variant-trait associations across 2068 traits. GTEx v11 eQTL analysis (based on expression data from 953 donors, using a cis-window approach at a false discovery rate below 5%) shows that rs11206670 is strongly associated with reduced expression of this locus in thyroid tissue (slope -0.39, p=2.7e-24) and with reduced expression of the neighboring gene ENSG00000297128 in the same tissue (slope -0.24, p=4.6e-10) GTEx Portal.
Reported associations
- Thyroid tissue expression of LINC01755 (eQTL): GTEx v11 data from 953 donors links rs11206670 to reduced expression of this locus in thyroid tissue; each additional copy of the alternative allele corresponds to a decrease in expression (slope -0.39, p=2.7e-24) GTEx Portal
- Thyroid tissue expression of ENSG00000297128 (eQTL): The same variant is associated with reduced expression of the neighboring ENSG00000297128 gene in thyroid tissue (slope -0.24, p=4.6e-10), indicating this variant's regulatory influence extends to at least one additional gene in the region GTEx Portal
Evidence quality The GTEx eQTL associations are well-powered, drawing on data from 953 donors in GTEx v11, with p-values of 2.7e-24 and 4.6e-10 for the two thyroid expression signals, both far below standard genome-wide significance thresholds GTEx Portal. The broader discovery context comes from the VA Million Veteran Program, encompassing 635,969 participants across diverse US population groups and 2068 traits; however, specific clinical trait or disease associations for rs11206670 are not described in the available study text. Overall, the gene-expression-level evidence is robust and drawn from a large donor cohort, while evidence linking this variant to specific health outcomes or clinical diagnoses is not established from the provided data and should be considered preliminary pending further study.
Tissue-specific expression effects
- LINC01755: Reduced expression in thyroid tissue across 953 GTEx donors; each additional copy of the alternative allele is associated with decreased expression (slope -0.39), at a p-value of 2.7e-24 GTEx Portal
- ENSG00000297128: Reduced expression in thyroid tissue for this second neighboring gene (slope -0.24, p=4.6e-10), indicating the variant's regulatory influence is not limited to the primary locus alone GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is LINC01755?
LINC01755 is a long intergenic non-coding RNA gene, meaning it lies between protein-coding genes and does not itself produce a protein. Non-coding RNA genes can play roles in regulating the activity of nearby genes, though the specific function of LINC01755 is not described in the available studies.
What does rs11206670 affect?
Based on GTEx eQTL data from 953 donors, rs11206670 is associated with reduced expression of LINC01755 and a neighboring gene (ENSG00000297128) in thyroid tissue. These are expression-level associations, not established links to any clinical disease or condition.
Is rs11206670 linked to thyroid disease?
The available data shows rs11206670 affects gene expression levels in thyroid tissue, but no link to a specific thyroid disease or clinical condition is established in the provided studies. The expression effects are biological observations about gene activity, not disease diagnoses.
Where was rs11206670 discovered?
This variant was catalogued in the VA Million Veteran Program (MVP), a large genome-wide association study of 635,969 US veterans across diverse population groups, published in Science in 2024.
What does an eQTL mean for this variant?
An eQTL (expression quantitative trait locus) is a genetic variant associated with differences in how much a nearby gene is expressed. For rs11206670, GTEx data from nearly 1,000 donors shows it is consistently linked to lower expression of LINC01755 in thyroid tissue, with a highly significant statistical signal.