Expressive

rs111970447 - GIP

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetic Determinants of Clustering of Cardiometabolic Risk Factors in U.K. Biobank. - Metabolic syndrome and related disorders (2021) · Lind L · PubMed 31928498

    The metabolic syndrome (MetS) is a description of a clustering of cardiometabolic risk factors in the same individual. This study searched for genetic loci associated with all five prespecified components of MetS to find a common pathophysiological link for this risk factor clustering. Using data from 291,107 individuals in the U.K. biobank, a genome-wide association study (GWAS) was performed versus each of the five components of the syndrome as continuous variables (glucose, systolic blood pressure, triglycerides, waist circumference, and high-density lipoprotein-cholesterol). Using false discovery rate <0.05, three loci were related to all five MetS components (rs7575523; nearest gene , rs3936511; intron of , and rs111970447; intron of ). Of those, seems the most interesting candidate f

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting blood glucose Moderate

    rs111970447 is associated with elevated fasting blood glucose (p=7e-6)

    Check fasting glucose at least annually

Diet

  • reduce sodium intake Moderate

    Lower sodium intake reduces blood pressure in genetically susceptible individuals

    Target less than 2300mg sodium per day

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise reduces both blood pressure and glucose, mitigating genetic predisposition

    150 minutes per week moderate-intensity aerobic activity

Screening

  • blood pressure screening Moderate

    rs111970447 is associated with increased systolic blood pressure (effect 0.287 mmHg, p=2e-7)

    Check blood pressure at least annually