rs111897777 (LINC01482): UK Biobank GWAS Variant
Key takeaways
- rs111897777 was analyzed in a UK Biobank GWAS of approximately 405,000 participants covering 13.3 million variants.
- The study covered 79 quantitative traits and 50 binary traits using a method that detects more associations than standard GWAS tools.
- Specific trait associations and effect sizes for this variant are not reported in the available study text.
- No lifestyle, dietary, or drug-response information is on file for this variant from available studies.
Key takeaways
- rs111897777 was analyzed in a UK Biobank genome-wide association study (GWAS) of approximately 405,000 participants covering 13.3 million variants.
- The study covered 79 quantitative traits and 50 binary (disease) traits using a statistical method shown to detect more associations than standard tools.
- Specific trait associations and effect sizes for this variant are not reported in the available study text.
- No lifestyle, dietary, or drug-response information is on file for this variant from available studies.
What the research says rs111897777, in the LINC01482 region, was included in a large-scale GWAS (Loya H et al., Nature Genetics, 2025) of approximately 405,000 UK Biobank participants spanning 13.3 million variants across 79 quantitative and 50 binary traits. The study used Quickdraws, a mixed-model method with a spike-and-slab prior (a statistical model that allows genetic effects to cluster at zero or at non-zero values, rather than assuming all variants have small, uniform effects) that identified 4.97% more quantitative trait associations and 3.25% more binary trait associations than the competing REGENIE method in the same dataset. Specific associations and effect sizes for this variant are not detailed in the available study text.
Reported associations
- UK Biobank multi-trait analysis: Analyzed across 79 quantitative and 50 binary traits in approximately 405,000 participants using the Quickdraws GWAS method; individual association results for this variant are not provided in the available study text.
Evidence quality The sole available study is a methods paper (Loya H et al., Nature Genetics, 2025) demonstrating the Quickdraws GWAS algorithm on approximately 405,000 UK Biobank individuals across 13.3 million variants. This paper does not report individual variant-level findings for rs111897777 in the text provided. No p-values, effect sizes, or replication statistics can be assessed for this variant from the available material, and evidence quality is therefore indeterminate. The study is not a replication study and does not benchmark this locus specifically.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs111897777?
rs111897777 is a genetic variant in the LINC01482 region. It was included in a large genome-wide association study of approximately 405,000 UK Biobank participants, though specific trait associations are not detailed in the available study text.
What traits is rs111897777 associated with?
The available study analyzed this variant across 79 quantitative and 50 binary traits in approximately 405,000 UK Biobank participants, but does not report individual association results for rs111897777 in the provided text.
What is the LINC01482 region?
LINC01482 is the genomic region where rs111897777 is located. The available study does not describe the biological function of this region.
How was rs111897777 studied?
This variant was analyzed using Quickdraws, a genome-wide association method that uses a spike-and-slab statistical model to improve detection power. The study covered approximately 405,000 UK Biobank participants and 13.3 million genetic variants across dozens of traits.
Is rs111897777 linked to any diseases?
The available study analyzed 50 binary traits including disease outcomes in UK Biobank participants, but does not provide specific results for this variant. No confirmed disease associations are documented in the available material.