Expressive

rs111803193 (MLN): UK Biobank GWAS signal

Key takeaways

  • Identified in a UK Biobank GWAS of ~405,000 people using Quickdraws, a new machine learning-based statistical method.
  • Quickdraws found roughly 5% more associations than the previous standard tool for quantitative traits in the same dataset.
  • No effect size or specific trait direction has been reported for this variant in the available study text.
  • Replication across Biobank Japan and FinnGen was assessed for the full set of findings from this analysis.
  • Evidence is preliminary and variant-specific details are not yet available.

Key takeaways

  • Identified as an association signal in a UK Biobank genome-wide association study of approximately 405,000 individuals using the Quickdraws method.
  • The analysis covered 79 quantitative and 50 binary traits, finding roughly 5% more associations than the previous standard tool for quantitative traits.
  • No variant-specific effect size, direction, or p-value is reported in the available study text.
  • Replication of findings from this analysis was assessed across Biobank Japan and FinnGen, though whether this specific variant replicated is not stated.
  • Evidence should be considered preliminary given the absence of variant-specific reporting.

What the research says This variant was surfaced as an association signal when Quickdraws, a machine learning-based genome-wide association method, was applied to approximately 405,088 UK Biobank participants across 79 quantitative and 50 binary traits. Quickdraws identified 4.97% more quantitative-trait associations than REGENIE and 22.71% more than FastGWA for quantitative traits in this dataset, with similar gains in replicated signals assessed in Biobank Japan and FinnGen. No effect size, p-value, or trait direction specific to rs111803193 is available in the provided study text.

Reported associations

  • MLN locus: Identified as an association signal through a UK Biobank genome-wide association study (n approximately 405,088); no variant-specific trait label or effect size is available in the provided study text.

Evidence quality The association was detected using Quickdraws applied to approximately 405,088 UK Biobank individuals, a large sample that confers substantial statistical power for genome-wide discovery. Quickdraws uses a spike-and-slab prior, a statistical model that assumes most genetic variants have zero effect while a smaller subset have meaningful effects, which can increase detection power compared to methods relying on fully polygenic Gaussian priors such as REGENIE and FastGWA. The provided study text does not include variant-specific statistics for this locus, making it impossible to assess the effect size, direction, p-value, or replication status of this particular signal. Evidence should be considered preliminary until variant-specific reporting becomes available.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs111803193?

rs111803193 is a genetic variant located at or near the MLN gene. It was identified as an association signal in a large genome-wide association study of over 400,000 UK Biobank participants.

What trait is rs111803193 associated with?

The study that identified this variant analyzed 79 quantitative and 50 binary traits, but the available text does not specify which trait rs111803193 is linked to or provide an effect size for this particular variant.

How was rs111803193 discovered?

It was identified using Quickdraws, a machine learning-based genome-wide association method that uses a spike-and-slab statistical prior and GPU acceleration. This approach found roughly 5% more associations than previous standard methods in the same UK Biobank dataset.

How reliable is the evidence for rs111803193?

The finding comes from a large sample of approximately 405,000 individuals, which provides good statistical power. However, variant-specific statistics such as effect size and p-value are not reported in the available study, so the strength of this particular association cannot be fully evaluated yet.