Expressive

rs11177417 (CPM): Blood Protein Level Variant

Key takeaways

  • rs11177417 is linked to CPM protein levels in blood, found in a UK Biobank study of over 54,000 participants.
  • The study used Olink proximity extension assay technology to measure about 1,463 circulating proteins simultaneously.
  • A ratio-based GWAS method used in this study increased total genetic signal discovery by about 24.7% over standard single-protein analysis.
  • Ratio QTLs from this study were 7.6-fold enriched in known protein-protein interactions, pointing to biological links between affected proteins.

Key takeaways

  • rs11177417 is a genetic variant associated with CPM protein levels in blood, identified in a UK Biobank proteomics study of over 54,000 participants.
  • The study measured approximately 1,463 circulating blood proteins using the Olink Explore 1536 proximity extension assay platform.
  • A ratio-based genome-wide association study (GWAS) approach used in this study increased total genetic signal discovery by about 24.7% compared to standard protein-level analysis.
  • Ratio QTLs (rQTLs) identified in this study were 7.6-fold enriched in known protein-protein interactions, suggesting that genetic effects on protein ratios reflect biological relationships between proteins.

What the research says rs11177417 was identified as a protein quantitative trait locus (pQTL) - a genetic location statistically associated with variation in a specific protein's blood levels - for CPM in a large-scale proteogenomics study using UK Biobank data (Suhre K, Cell Genomics, 2024). The study analyzed Olink proximity extension assay measurements of approximately 1,463 blood-circulating proteins in over 54,000 participants using a dual-antibody binding technique called the proximity extension assay. Extending the analysis to ratios between pairs of proteins identified 4,248 associations with 2,821 protein ratios and increased the overall number of discovered genetic loci by 24.7% over standard single-protein GWAS.

Reported associations

  • CPM protein levels in blood: rs11177417 is associated with circulating levels of this protein, identified using Olink Explore 1536 proteomics data from over 54,000 UK Biobank participants. Specific effect size data for this variant are not reported in the available study text.

Evidence quality The association for rs11177417 was reported in a single large study (Suhre K, Cell Genomics, 2024) using a sample of over 54,000 UK Biobank participants, which represents a substantial discovery cohort. No independent replication in a separate cohort is described in the available study text for this specific variant, and specific p-values and effect sizes are not provided in the study text supplied here, limiting quantitative evaluation. The overall study used the Olink Explore 1536 platform, which the UK Biobank Pharma Proteomics Project consortium - a precompetitive consortium of 13 biopharmaceutical companies - previously used to identify over 10,000 pQTLs across the proteome. The evidence for this variant should be considered preliminary pending external replication.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs11177417?

rs11177417 is a single nucleotide polymorphism (SNP) - a common type of genetic variation - that has been linked to levels of the CPM protein circulating in blood. It was identified in a large UK Biobank proteomics study of over 54,000 participants.

What protein does rs11177417 affect?

rs11177417 is associated with levels of the CPM protein in blood. This association was identified using the Olink Explore 1536 platform, which measures approximately 1,463 circulating proteins using a dual-antibody binding technique.

How strong is the evidence linking rs11177417 to CPM?

The association was found in a single large discovery study of over 54,000 participants. No independent replication in a separate cohort is described in the available study text for this specific variant, so the evidence should be considered preliminary.

What is a protein quantitative trait locus (pQTL)?

A pQTL is a location in the genome where genetic variation is statistically associated with differences in the measured level of a specific protein in blood or tissue. rs11177417 is a pQTL for the CPM protein.

What is the UK Biobank Pharma Proteomics Project?

The UK Biobank Pharma Proteomics Project is a precompetitive consortium of 13 biopharmaceutical companies that funded the measurement of approximately 1,463 blood-circulating proteins in over 54,000 participants using the Olink Explore 1536 proximity extension assay, generating one of the largest protein-level genetic datasets available and identifying over 10,000 pQTLs.