rs111605439 (CLPSL2): UK Biobank GWAS Variant

Key takeaways

• rs111605439 falls in the CLPSL2 gene region and has appeared in large-scale UK Biobank genomic research involving approximately 405,000 individuals
• The only available study is a methodology paper (Quickdraws; Loya H, Kalantzis G, Cooper F, and Palamara PF; Nature Genetics, 2025) that analyzed 79 quantitative and 50 binary traits but does not report specific associations for this variant in the provided text
• No trait, disease, or lifestyle associations are currently documented for rs111605439 in the provided evidence
• Effect sizes, p-values, and replication data specific to this variant are not available from the provided study

What the research says The only study on file for this variant is a methods paper introducing Quickdraws, a scalable mixed-model genome-wide association algorithm (meaning a computational tool that links genetic variants to traits across millions of data points), applied to 405,088 UK Biobank individuals (Loya H, Kalantzis G, Cooper F, and Palamara PF; Nature Genetics, 2025). That study analyzed 13.3 million variants across 79 quantitative and 50 binary traits, identifying 4.97% and 3.25% more associations than the REGENIE method for quantitative and binary traits, respectively. The available study text does not report a specific association between rs111605439 and any trait, and no variant-level statistics for this locus are included in the provided excerpt.

Reported associations

• No variant-specific associations reported: The available study text does not document a specific association between rs111605439 in the CLPSL2 locus and any trait, disease, or condition. The parent study analyzed large-scale UK Biobank data using the Quickdraws algorithm but does not name this variant in the provided text.

Evidence quality The single available study applied the Quickdraws algorithm to approximately 405,000 UK Biobank participants across 79 quantitative and 50 binary traits (Loya H et al., Nature Genetics, 2025). The method achieved replicated signals in Biobank Japan and FinnGen for its broadly discovered associations. However, no p-values, odds ratios, beta coefficients, or other statistics specific to rs111605439 appear in the available text. The evidence base for this specific variant's effects is therefore insufficient to characterize from the provided study alone.

Lifestyle considerations No lifestyle considerations on file for this variant.