rs111435886 (Y_RNA-CARS1P2): Gut Microbiome GWAS
Key takeaways
- rs111435886 sits in the Y_RNA-CARS1P2 region and has been examined in gut microbiome genetics research
- The source study spanned roughly 3,890 European participants across three independent cohorts
- Specific association data for this variant is not described in the available study text
- Gut microbiome GWAS signals show poor overlap across independent studies, making single-study signals hard to interpret
Key takeaways
- rs111435886 is a genetic variant located in the Y_RNA - CARS1P2 genomic region
- It has been examined in the context of gut microbiome genome-wide association research spanning roughly 3,890 European participants
- Specific association statistics for this variant are not described in the available study excerpt
- Gut microbiome GWAS findings have shown poor replication across independent studies, limiting interpretive confidence
- No lifestyle or clinical implications are supported by the current evidence base for this variant
What the research says rs111435886 is located in the Y_RNA - CARS1P2 genomic region. A multi-cohort gut microbiome genome-wide association study (GWAS) examined host genetic contributions to microbial community composition across three European populations - the Flemish Gut Flora Project (FGFP, n=2,223), the FoCus cohort (n=950), and the PopGen cohort (n=717) - analyzing up to 157 microbial traits, though specific association statistics for this variant are not reported in the provided study text. The study authors noted that environmental variables dominate gut microbiome variation and that overlap between genetic signals across independent microbiome GWAS studies is poor, complicating interpretation of any individual signal.
Reported associations
- Gut microbiome variation: This variant was examined in a GWAS of gut microbiota traits across three European cohorts; the provided study text does not describe a specific confirmed association between rs111435886 and any named microbial taxon, alpha-diversity measure, or community composition type.
Evidence quality The source study analyzed 157 microbial traits (92 abundance profiles, 62 presence/absence phenotypes, three alpha-diversity measures, one enterotype classification, and one beta-diversity measure) across approximately 3,890 participants. Two associations reached a study-level significance threshold of p < 1.57x10-10, and 11 others met a suggestive threshold of p < 2.5x10-8. Heritability estimates for gut microbial traits ranged from 0 to 0.47 across the cohort. No p-value, odds ratio, beta coefficient, or effect size for rs111435886 is described in the provided study excerpt, and replication status for this specific variant cannot be assessed from the available text. The authors explicitly cautioned that inter-study analytical variation and the dominance of environmental factors over genetic factors in microbial trait variation limit confidence in any individual GWAS signal.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs111435886?
rs111435886 is a single nucleotide polymorphism (a type of genetic variant, meaning a single letter change in the DNA sequence) located in the Y_RNA - CARS1P2 region of the genome. It has appeared in research on how human genetics influences gut microbiome composition.
What is the Y_RNA - CARS1P2 region?
Y_RNA elements are small non-coding RNA molecules involved in cellular processes, and CARS1P2 is a pseudogene, meaning a non-functional copy of a gene. The specific biological roles of these elements in relation to gut microbiome traits are not described in the available study literature.
Is rs111435886 linked to differences in gut bacteria?
This variant has appeared in genome-wide association research on gut microbiome variation, but specific association statistics linking it to named bacterial taxa or diversity measures are not available in the provided study excerpt.
How reliable is the evidence for rs111435886?
Evidence is very preliminary. The source study noted that overlap between gut microbiome GWAS signals across independent studies is generally poor, and no confirmed, replicated association for this specific variant is described in the available text.
What is a gut microbiome GWAS?
A gut microbiome genome-wide association study (GWAS) scans hundreds of thousands of genetic variants across the genome to find ones that correlate with differences in gut bacterial communities. These studies typically require very large sample sizes and independent replication before findings are considered reliable.