rs1114148 (LINC01515): PTSD Risk Variant

Key takeaways

• rs1114148 near LINC01515, a long non-coding RNA gene, was identified as one of 95 genome-wide significant genetic loci associated with posttraumatic stress disorder (PTSD)
• The discovery study is one of the largest psychiatric genetics analyses conducted, combining data from 88 cohorts and over 1.28 million participants across multiple ancestries
• 80 of the 95 identified loci were newly discovered, meaning most, including this one, have limited independent replication to date
• LINC01515 is a long intergenic non-coding RNA (lncRNA), a gene class that does not produce a protein, and its specific biological role in PTSD is not yet characterized in the available evidence
• No per-locus effect size for this specific variant was reported in the available study text

What the research says

A multi-ancestry genome-wide association study (GWAS) meta-analysis -- a method that scans the entire genome across many datasets to find variants statistically tied to a trait -- combined data from 88 separate cohorts totaling 1,222,882 individuals of European ancestry (137,136 PTSD cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). The analysis yielded 95 genome-wide significant risk loci for PTSD, of which 80 were newly reported, with rs1114148 near LINC01515 among the variants identified at the genome-wide significance threshold. The broader locus-discovery effort used convergent multi-omic approaches to nominate 43 putative causal genes, grouped into categories including neurotransmitter and ion channel modulators, developmental and transcription factors, synaptic structure genes, and endocrine or immune regulators.

Reported associations

• Posttraumatic stress disorder (PTSD): rs1114148, located near LINC01515, reached genome-wide significance for association with PTSD in a multi-ancestry GWAS meta-analysis of 88 cohorts (n = 1,222,882 European ancestry individuals plus 58,051 admixed individuals; specific per-locus effect size for this variant not reported in the available study excerpt)

Evidence quality

The identifying study is among the most well-powered psychiatric genetics analyses published, with a combined sample exceeding 1.28 million individuals and more than 150,000 PTSD cases, lending strong statistical power to locus-level findings overall. However, 80 of the 95 reported loci were described as novel, meaning that independent replication in separate published datasets is not yet established for most of them, including this locus. LINC01515 is classified as a long intergenic non-coding RNA, a gene class whose functional mechanisms in neural tissue are generally less well understood than protein-coding genes, adding biological uncertainty about the pathway through which this locus might influence PTSD. No specific p-value, odds ratio, or percentage-of-variance figure for rs1114148 was available in the provided study text, limiting evaluation of the magnitude of this individual association.

Lifestyle considerations

No lifestyle considerations on file for this variant.