rs11105570 (LINC02392/LINC02822): Adult Height Variant

Key takeaways

• rs11105570 is one of 12,111 common variants linked to adult height in the largest height genetics study ever published, covering 5.4 million people
• It sits in the LINC02392 - LINC02822 region, within one of 7,209 genomic segments together covering about 21% of the human genome
• All common height variants in this study together explain roughly 40-45% of height variation in people of European ancestry
• Prediction is weaker in non-European populations (10-24%), attributed to statistical differences between populations rather than different biology
• No lifestyle factors or drug responses have been linked to this specific variant in the available evidence

What the research says rs11105570, located in the LINC02392 - LINC02822 region (LINC is a standard gene nomenclature prefix standing for Long Intergenic Non-Coding RNA, meaning these genes produce RNA molecules but not proteins), is among 12,111 independent common SNPs (single-nucleotide polymorphisms, or single-letter differences in the DNA sequence) significantly associated with adult height in a genome-wide association study (GWAS) of 5,380,080 individuals from 281 studies spanning five broad ancestry groups. Together, the full set of common height variants in this study accounts for approximately 40-45% of phenotypic variance (the share of height differences between people explained by common genetic variants) in European-ancestry populations, but only around 10-24% in non-European populations. Effect sizes and associated regions are described as broadly similar across ancestry groups, with reduced prediction accuracy in non-European populations attributed to differences in linkage disequilibrium (the tendency for nearby DNA variants to be co-inherited) and allele frequency rather than fundamentally different biology.

Reported associations

• Adult height: rs11105570 is one of 12,111 common variants significantly associated with adult height in a GWAS of 5,380,080 individuals across multiple ancestry groups; this set of variants collectively explains approximately 40-45% of phenotypic variance in European-ancestry populations and 10-24% in non-European populations, though a per-allele effect size specific to this variant is not reported in the available study text

Evidence quality This association derives from the largest height GWAS reported to date, encompassing 5,380,080 participants from 281 contributing studies across five broad ancestry groups (approximately 76% of predominantly European ancestry, with the remainder spanning East Asian, Hispanic, African, and South Asian groups). The study identifies 12,111 genome-wide significant associations and characterizes this as approaching saturation of common variant discovery for height in European-ancestry populations. No variant-specific effect size or replication result for rs11105570 is reported in the provided text. Prediction accuracy is substantially lower in non-European ancestry groups (10-24% versus 40-45% in European samples), which the authors attribute to linkage disequilibrium structure and allele frequency differences rather than biological divergence. Further research is noted as necessary to achieve equivalent discovery coverage in non-European populations.

Lifestyle considerations No lifestyle considerations on file for this variant.