rs1107560 (MAGI2): Genetic Variant Overview

Key takeaways

• No studies in the provided dataset report direct associations for rs1107560 or the MAGI2 locus
• The only available study in this dataset examines a different variant in a different gene unrelated to this locus
• No trait associations, effect sizes, or lifestyle data can be reported for rs1107560 from the available literature

What the research says The only study provided for this entry examines the genetic determinants of serum bilirubin (a pigment produced from the breakdown of red blood cells) in 707 admixed Chilean adolescents and does not report any findings for rs1107560 or the MAGI2 gene. That study identifies a variant near UGT1A1, the liver enzyme responsible for bilirubin conjugation (a chemical process that makes bilirubin water-soluble for excretion), as the dominant genome-wide signal for bilirubin levels, explaining between 28.4% and 37.6% of bilirubin variance depending on ancestry component. No evidence concerning rs1107560 can be derived from the provided literature.

Reported associations

• No associations for rs1107560 are reported in the provided studies.

Evidence quality No studies in the provided dataset contain data on rs1107560 or MAGI2. The sole available study, which examined 707 Chilean adolescents and was published in Frontiers in Genetics (2024), addresses a different variant and phenotype entirely. Evidence quality for rs1107560 cannot be assessed without relevant studies in the dataset.

Lifestyle considerations No lifestyle considerations on file for this variant.