rs11030393 (METTL15): Genetic Variant Linked to Height

Key takeaways

• rs11030393 is one of 12,111 independent common variants reported as associated with adult height in a meta-analysis of 5.4 million individuals across 281 studies
• The full set of identified height variants collectively explains about 40% of height variation in European-ancestry populations (45% using the broader HapMap 3 panel)
• Prediction accuracy from these variants is lower in non-European ancestry groups due to differences in linkage disequilibrium and allele frequencies across populations
• No specific per-allele effect size for rs11030393 individually is available in the provided study text
• No lifestyle or drug response data specific to this variant has been identified in current research

What the research says rs11030393, at the METTL15 - LINC02758 locus, was identified as a height-associated common variant in a genome-wide association study (GWAS, a method that tests hundreds of thousands of DNA positions simultaneously across many people) of 5.4 million individuals spanning five major ancestry groups. The study identified 12,111 independent height-associated single-nucleotide polymorphisms (SNPs, single-letter DNA differences between individuals) clustered across 7,209 genomic segments averaging approximately 90 kilobases in length, together covering about 21% of the human genome. These 12,111 SNPs account for approximately 40% of phenotypic variance in height in European-ancestry populations and roughly 45% when all HapMap 3 reference panel variants are considered, but explain only around 10-20% of variance in non-European populations.

Reported associations

• Adult height: rs11030393 is among 12,111 common SNPs identified as independently associated with adult stature in a GWAS meta-analysis of 5.4 million participants; the per-allele effect size for this individual variant is not reported in the available study text

Evidence quality Evidence for rs11030393 rests on a single large meta-analysis incorporating 5.4 million individuals across 281 studies, representing one of the largest genetic studies of height conducted. Participants spanned five major ancestry groups: European (approximately 4.1 million, 75.8%), East Asian (472,730, 8.8%), Hispanic/admixed (455,180, 8.5%), African (293,593, 5.5%), and South Asian (77,890, 1.4%). The study found that effect sizes and associated genomic regions are broadly consistent across ancestry groups, though linkage disequilibrium (statistical correlation between neighboring DNA variants) and allele frequency differences explain why prediction accuracy is lower in non-European populations. The specific p-value and per-allele effect size for rs11030393 are not included in the available study text, which limits assessment of the strength of this particular association. No independent replication cohort data specific to this variant is described in the provided text.

Lifestyle considerations No lifestyle considerations on file for this variant.