Expressive

rs11024600 - SAA1 - HPS5

Magnitude 2.2 · 1 study on file

Reported associations

  • Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease - Unknown journal (n.d.) · Unknown authors · PubMed 36578646

    ABSTRACT: Objectives: Circulating serum amyloid A (SAA) levels are strongly associated with atherosclerotic cardiovascular disease risk and severity. The association between SAA1 genetic variants, SAA levels, inflammatory marker levels, and coronary artery disease (CAD) prognosis has not been fully understood. Materials and Methods: In total, 2199 Taiwan Biobank (TWB) participants were enrolled for a genome-wide association study (GWAS), and the long-term outcomes in 481 patients with CAD were analyzed. The primary endpoint was all-cause mortality, and the secondary endpoint was the combination of all-cause death, myocardial infarction, stroke, and hospitalization for heart failure. Results: Through GWAS, SAA1 rs11024600 and rs7112278 were independently associated with SAA levels (P = 3.84

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Anti-inflammatory dietary pattern Moderate

    Elevated SAA reflects systemic inflammation; dietary patterns modulate SAA expression and associated inflammatory markers

    Emphasize whole foods, omega-3 fatty acids, antioxidant-rich vegetables; limit processed foods and refined sugars

Discuss with your doctor

  • Individualized cardiovascular risk monitoring strategy Moderate

    Genetic predisposition to elevated SAA warrants personalized assessment and monitoring plan given its independent predictive value for cardiovascular outcomes

Lifestyle

  • Maintain healthy weight and metabolic markers Moderate

    SAA levels show strong positive association with BMI and metabolic factors; weight reduction may lower SAA levels and associated inflammatory markers

    Target BMI 18.5-24.9 kg/m2; monitor metabolic markers

Screening

  • Serum amyloid A (SAA) level testing and cardiovascular risk assessment Moderate

    rs11024600 C allele strongly increases SAA levels (GWAS p=3.84e-145); elevated SAA independently predicts cardiovascular mortality and major adverse events

    Obtain baseline SAA level; repeat annually or per physician if elevated