Expressive

rs11023332 - PDE3B

Magnitude 2.2 · 4 studies on file

Reported associations

  • Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. - Genes and immunity (2015) · Anderson D, Holt BJ, Pennell CE, Holt PG, Hart PH, Blackwell JM · PubMed 25208829

    This genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels measured in blood collected at age 6 years (n=673) and at age 14 years (n=1140). Replication of significantly associated genes from previous GWASs was found for both ages. Genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in PDE3B/CYP2R1 (age 6: rs1007392, P=3.9 × 10(-8); age14: rs11023332, P=2.2 × 10(-10)) and on chromosome 4q13 in GC (age 6: rs17467825, P=4.2 × 10(-9); age14: rs1155563; P=3.9 × 10(-9)). In addition, a novel association was observed at age 6 with SNPs on chromosome 7p15 near NPY (age 6: rs156299, P=1.3 × 10(-6)) that could be of fun

  • Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study - Unknown journal (n.d.) · Unknown authors · PubMed 34852423

    ABSTRACT: Background Epidemiological data have shown that vitamin D deficiency is highly prevalent in Korea. Genetic factors influencing vitamin D deficiency in humans have been studied in Europe but are less known in East Asian countries, including Korea. We aimed to investigate the genetic factors related to vitamin D levels in Korean people using a genome-wide association study (GWAS). Methods We included 12,642 subjects from three different genetic cohorts consisting of Korean participants. The GWAS was performed on 7,590 individuals using linear or logistic regression meta- and mega-analyses. After identifying significant single nucleotide polymorphisms (SNPs), we calculated heritability and performed replication and rare variant analyses. In addition, expression quantitative trait lo

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals - Unknown journal (n.d.) · Unknown authors · PubMed 22479202

    ABSTRACT: Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8-1.2×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate region

  • A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin - Unknown journal (n.d.) · Unknown authors · PubMed 37859345

    ABSTRACT: Summary Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 diabetes and obesity, identified >20 associated loci. However, most loci were identified in populations of European ancestry, and many of the target genes underlying the associations remain unknown. We conducted a cross-ancestry adiponectin GWAS meta-analysis in 46,434 individuals from the Metabolic Syndrome in Men (METSIM) cohort and the ADIPOGen and AGEN consortiums. We combined study-specific association summary statistics using a fixed-effects, inverse variance-weighted approach. We identified 22 loci associated with adiponectin (p < ), including 15 known and seven previously unreported loci. Among individuals of European ancestry, Genome-wide Complex Traits Analysis j

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Metabolic panel and adiponectin levels Moderate

    rs11023332-C allele associates with lower adiponectin, an insulin-sensitizing hormone involved in metabolic health

    Annual fasting glucose, lipid panel; adiponectin if available

Diet

  • Vitamin D-rich foods Moderate

    Dietary sources contribute to vitamin D status; genetic predisposition to deficiency makes dietary intake particularly important

    Include fatty fish, egg yolks, fortified dairy; 2-3 servings weekly

Lifestyle

  • Regular moderate sun exposure Moderate

    Cutaneous vitamin D synthesis depends on UVB exposure; genetic predisposition to lower vitamin D may be partially offset by adequate sun exposure

    15-30 minutes midday sun 3-4 times weekly, when feasible

Screening

  • Serum 25-hydroxyvitamin D levels High

    rs11023332-C allele predisposes to lower vitamin D through altered PDE3B expression affecting vitamin D metabolism

    Check annually; target level >30 ng/mL (>75 nmol/L)

Supplements

  • Vitamin D3 supplementation High

    Genetic predisposition to lower vitamin D may require supplementation to maintain adequate serum concentrations

    1000-2000 IU daily; adjust based on serum 25(OH)D levels