rs11023007 (LINC02545): Subclinical Atherosclerosis
Key takeaways
- rs11023007 sits in the LINC02545/RNA5SP331 locus, a region of non-coding RNA genes, and was studied in a genome-wide scan of arterial wall thickness.
- The study tracked carotid artery intima-media thickness (cCIMT), a validated early-warning measure for heart attack and stroke risk.
- The analysis covered 970 Black, non-Hispanic women (682 HIV-positive, 288 HIV-negative) and no variant crossed the genome-wide significance threshold.
- Evidence is from a single cohort and has not been replicated; findings are preliminary.
Key takeaways
- rs11023007 is located in the LINC02545/RNA5SP331 locus, a region of non-coding RNA genes, and was examined in a genome-wide association study of subclinical atherosclerosis.
- The study measured common carotid artery intima-media thickness (cCIMT), a non-invasive ultrasound measure of arterial wall thickening used to predict cardiovascular disease events.
- Evidence comes from a single study of 970 Black, non-Hispanic women (682 HIV-positive, 288 HIV-negative); no variant in the study reached genome-wide statistical significance.
- All findings are preliminary and require independent replication before any conclusions can be drawn.
What the research says A genome-wide association and admixture study in the Women's Interagency HIV Study (WIHS) cohort examined cCIMT across 682 HIV-positive and 288 HIV-negative Black, non-Hispanic women, finding only suggestive, sub-threshold associations with no variant achieving the conventional genome-wide significance cutoff of p < 5 x 10^-8. Admixture mapping - a method that identifies genomic regions where disease-associated variants are unevenly distributed across ancestral populations - was applied alongside the GWAS, and results indicated that local European ancestry plays an important role in cCIMT genetic associations among Black women in this cohort. The authors called for confirmation of all findings in independent samples.
Reported associations
- Subclinical atherosclerosis (cCIMT): The GWAS and admixture analysis of common carotid artery intima-media thickness in the WIHS cohort (n=970) provides the available evidence linking this locus to a cardiovascular-related trait; the study reported only sub-genome-wide-significant associations across the genome, and no effect size or precise p-value specific to rs11023007 was reported in the available study text.
Evidence quality Evidence for rs11023007 derives from a single GWAS and admixture study in 970 Black, non-Hispanic women from the WIHS cohort (682 HIV-positive, 288 HIV-negative). No association in the study reached genome-wide statistical significance (p < 5 x 10^-8), and the authors explicitly called for independent replication. No effect size or precise p-value for this specific variant appears in the provided study text. This represents preliminary, single-cohort evidence without replication.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs11023007?
rs11023007 is a genetic variant located near the LINC02545 and RNA5SP331 genes. It was identified in a genome-wide study examining subclinical markers of arterial disease in Black women with and without HIV.
What is LINC02545?
LINC02545 is a long intergenic non-coding RNA gene, meaning it produces an RNA molecule that does not code for a protein. Its specific biological function is not fully characterized.
Is rs11023007 linked to heart disease?
A single genome-wide study found a suggestive association between the LINC02545/RNA5SP331 locus and carotid artery wall thickness, a measure tied to cardiovascular disease risk. The finding did not reach genome-wide significance and has not been independently replicated.
What is carotid intima-media thickness (cCIMT)?
Carotid intima-media thickness (cCIMT) is a non-invasive ultrasound measurement of the inner layers of the carotid artery wall in the neck. Greater thickness indicates early-stage atherosclerosis and is a recognized predictor of future heart attack and stroke.
How strong is the evidence for rs11023007?
Evidence is preliminary. The variant was examined in one study of 970 Black women and the associated locus did not reach genome-wide statistical significance. Independent replication in other cohorts is needed before any conclusions can be drawn.