rs10996914 (CTNNA3): Late-Life Memory Genetics

Key takeaways

• rs10996914 is a variant in or near the CTNNA3 gene and has been studied in a large sex-stratified genome-wide analysis of late-life memory in older adults.
• The source research used harmonized memory composite scores from four cognitive aging and Alzheimer's disease cohorts, totaling approximately 27,000 participants.
• Memory heritability was found to be broadly similar in men and women, while some specific genetic drivers appear to differ by sex.
• Specific association data for rs10996914 are not detailed in the available study sources, so evidence for this variant should be considered preliminary.
• The study identified sex-specific pathways and genetic correlations linking memory performance to cardiovascular, immune, and education-related traits.

What the research says rs10996914, a variant at this locus, was included in a large sex-aware genome-wide association study (GWAS) of late-life memory performance that enrolled 27,583 participants (11,942 males and 15,641 females) drawn from four cohorts of cognitive aging and Alzheimer's disease research, spanning 24,216 non-Hispanic White and 3,367 non-Hispanic Black older adults. The study used harmonized memory composite scores across cohorts and performed both sex-stratified and sex-interaction analyses. Overall, investigators found that the heritable component of late-life memory is broadly comparable across sexes, while sex-stratified analyses identified distinct genetic loci, a heparan sulfate signaling pathway, and genetic correlations between memory and cardiovascular, immune, and education-related traits.

Reported associations

• Late-life memory performance: rs10996914 was included in sex-stratified and sex-interaction GWAS analyses of memory performance in older adults across cognitive aging and Alzheimer's disease cohorts. Specific p-values, odds ratios, or effect sizes for this variant are not available in the provided study sources.

Evidence quality The source study represents the largest sex-aware genetic analysis of late-life memory conducted to date, with approximately 27,000 participants across four harmonized cohorts, providing substantial statistical power for detecting sex-specific genetic effects on memory. The study's genome-wide significant sex-specific findings were rs67099044 (CBLN2), rs719070 (SCHIP1/IQCJ-SCHIP), and rs5935633 (EGL6/TCEANC/OFD1 on the X chromosome); rs10996914 is not among these highlighted results. Specific statistics for this variant, including p-values and effect sizes, are absent from the available study excerpt, and replication status cannot be assessed. Evidence for any specific association between rs10996914 and late-life memory performance should be considered preliminary.

Lifestyle considerations No lifestyle considerations on file for this variant.