rs10958605 - LINC02866 - SIRLNT

Magnitude 4.5 · 1 study on file

Reported associations

• Genomic determinants of motor and cognitive outcomes in Parkinson's disease - Unknown journal (n.d.) · Unknown authors · PubMed 22658654

  ABSTRACT: Background Little is known regarding genetic factors associated with motor or cognitive outcomes in Parkinson's disease (PD). Objective To identify common genetic variants associated with motor and cognitive outcomes in PD. Methods The sample consisted of 443 PD cases included in the first genome-wide association study (GWAS) of PD. Methods included telephone interview assessments of motor and cognitive outcomes, a median 9 years following the initial clinical assessments. Analyses included Cox proportional hazard models to study the association of 198,345 single nucleotide polymorphisms (SNPs) with survival free of Hoehn-Yahr Stage ≥4 (motor outcome), and either TICS-M ≤27 or AD-8 ≥2 (cognitive outcomes). Results The SNP rs10958605 in the C8orf4 gene had the smallest p-v

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