rs10946491 CASC15: thicker corneas
Upload your raw genetic data once, we'll show you which variants you carry and what the research says.
Key takeaways
- - Central corneal thickness is linked to this variant.
- - The T allele is associated with thicker corneas.
Key takeaways
- Central corneal thickness is linked to this variant.
- The T allele is associated with thicker corneas.
What the research says This variant is associated with central corneal thickness [PMID 35446358]. The T allele is linked to thicker corneas [PMID 35446358].
Reported associations
- Central corneal thickness: this variant increases thickness with a reported effect size of 1.57 p=9e-9 in about 17 thousand individuals [PMID 35446358].
Evidence quality The evidence comes from a genome-wide association study of about 17 thousand individuals reporting an effect size of 1.57 and a very low p-value of 9e-9 [PMID 35446358] No other studies are provided so replication is not reported.
Last lifestyle considerations on file for this variant.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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central corneal thickness and glaucoma risk Moderate
CASC15 rs10946491 variants associated with higher corneal thickness influence intraocular pressure measurements and glaucoma risk stratification.
Baseline corneal thickness measurement and glaucoma risk discussion with ophthalmologist
Frequently asked questions
What does rs10946491 mean?
rs10946491 in CASC15 is a genetic change that has been linked to slightly thicker corneas. The T allele is associated with thicker corneas.
Is this variant related to eye disease?
The study only shows an association with corneal thickness not other eye conditions.
Can I test for rs10946491?
You can check your DNA file for the T allele but it is a common change and does not require testing.