Expressive

rs10937355 (LPP): Childhood Obesity GWAS Variant

Key takeaways

  • rs10937355 sits at the LPP locus and was identified in a genome-wide scan of childhood obesity traits in 815 Hispanic children
  • The VIVA LA FAMILIA Study measured over 50 phenotypes including body composition, metabolites, hormones, inflammation, diet, and energy expenditure
  • GTEx v11 data from 953 donors link the alternate allele to reduced LPP-AS1 expression specifically in testis tissue
  • This is a single-population finding without reported independent replication, so results are preliminary

Key takeaways

  • rs10937355 sits at the LPP (LIM domain containing preferred translocation partner) locus and was identified in a genome-wide association study of childhood obesity traits in 815 Hispanic children
  • The VIVA LA FAMILIA Study genotyped 1.1 million SNPs across more than 50 phenotypes spanning body composition, metabolites, hormones, inflammation, diet, and energy expenditure
  • GTEx v11 data from 953 donors link the alternate allele to reduced LPP-AS1 expression specifically in testis tissue
  • Evidence derives from a single study population with no reported independent replication in the provided evidence; results are preliminary

What the research says The VIVA LA FAMILIA Study performed a genome-wide scan of 1.1 million single nucleotide polymorphisms (SNPs, sites in the genome where individuals differ by a single DNA letter) across 815 Hispanic children from 263 families recruited in Houston, TX, covering traits including anthropometry, body composition, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization, and physical activity; rs10937355 was identified within the scope of this childhood obesity GWAS (Comuzzie AG et al., PLoS One, 2013). Separately, functional data from GTEx v11 (953 donors, FDR<0.05) show the alternate allele at this locus is associated with reduced expression of LPP-AS1, a long non-coding antisense RNA (a regulatory RNA molecule that does not produce protein, transcribed from the strand opposite the LPP gene) in testis tissue, with a per-allele expression slope of -0.15 (p=2.1e-5) GTEx Portal.

Reported associations

  • Childhood obesity-related traits (Hispanic population): Identified in a GWAS of 815 Hispanic children examining anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, and physical activity (Comuzzie AG et al., PLoS One, 2013); the specific trait or traits reaching genome-wide significance for rs10937355 individually are not detailed in the provided text
  • LPP-AS1 expression in testis: The alternate allele is associated with reduced LPP-AS1 expression in testis (GTEx v11, 953 donors, slope -0.15, p=2.1e-5) GTEx Portal

Evidence quality The GWAS evidence comes from a single study of 815 Hispanic children (Comuzzie AG et al., PLoS One, 2013); the specific trait association and summary statistics for rs10937355 are not detailed in the provided text excerpt, limiting direct assessment of effect size and statistical confidence for this variant in that study. The study applied measured genotype analysis across more than 50 phenotypes using 1.1 million SNPs, providing a broad but hypothesis-generating scan. No replication in independent cohorts is reported in the provided evidence. The GTEx eQTL signal for LPP-AS1 in testis (p=2.1e-5, n=953 donors) draws on a large multi-tissue atlas with FDR-controlled significance, but eQTL findings describe a regulatory mechanism rather than a disease outcome GTEx Portal. Overall, available evidence for this variant is preliminary.

Tissue-specific expression effects

  • LPP-AS1: Reduced expression in testis in carriers of the alternate allele (GTEx v11, 953 donors, FDR<0.05) GTEx Portal

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is the LPP gene?

LPP stands for LIM domain containing preferred translocation partner. The locus also produces LPP-AS1, a long non-coding antisense RNA whose expression in testis tissue is influenced by rs10937355 according to GTEx functional genomic data.

What traits is rs10937355 associated with?

rs10937355 was identified in a genome-wide scan of childhood obesity-related traits in Hispanic children, a study covering anthropometry, body composition, metabolites, hormones, inflammation, diet, and energy expenditure. The specific trait most strongly linked to this variant is not detailed in the available evidence.

What does GTEx show for rs10937355?

GTEx v11 data from 953 donors show that the alternate allele of rs10937355 is associated with reduced LPP-AS1 expression in testis tissue (p=2.1e-5, FDR<0.05). This is a regulatory finding and does not directly indicate a clinical outcome.

Has rs10937355 been replicated in multiple studies?

The provided evidence comes from a single GWAS conducted in 815 Hispanic children. No independent replication is reported in the available studies, so findings should be considered preliminary.

What was the VIVA LA FAMILIA Study?

The VIVA LA FAMILIA Study enrolled 815 Hispanic children from 263 families in Houston, TX between 2000 and 2005 to map genetic variants influencing childhood obesity and related biological processes. It used 1.1 million SNP genotyping alongside detailed measurements of metabolism, diet, body composition, and physical activity.