rs10935179 (MSL2): Blood Biomarker Locus, UK Biobank

Key takeaways

• rs10935179 at the MSL2 gene locus was identified in a genome-wide study of 35 blood and urine biomarkers across 363,228 UK Biobank participants
• The study identified 1,857 genomic loci linked to at least one biomarker trait, with fine-mapping narrowing these to 3,374 high-confidence association sites
• Polygenic risk score models built from this study improved genetic risk prediction for chronic kidney disease, type 2 diabetes, gout, and alcoholic cirrhosis
• Findings were validated in an independent Finnish cohort (FinnGen, n=135,500)
• The specific biomarker trait linked to this variant is part of the study's supplementary locus catalog and is not reproduced in the excerpt provided

What the research says A genome-wide association study of 35 blood and urine biomarkers in 363,228 UK Biobank participants, spanning White British, non-British White, African, and South Asian ancestry groups, identified 1,857 genomic loci associated with at least one biomarker trait; rs10935179 at the MSL2 gene locus appears among those findings. The study performed detailed fine-mapping, yielding 3,374 fine-mapped associations, and applied Mendelian Randomization analysis to identify 51 causal relationships between biomarkers and 40 medically relevant phenotypes. The provided study excerpt does not specify the individual biomarker trait or effect size attributed to this variant.

Reported associations

• Blood or urine biomarker (UK Biobank, n=363,228): rs10935179 at the MSL2 locus was identified among 1,857 biomarker-associated genomic loci across 35 blood and urine traits; the specific trait association is part of the study's comprehensive supplementary catalog but is not detailed in the provided excerpt

Evidence quality The UK Biobank biomarker genome-wide association study used a large multi-ancestry discovery sample (n=363,228) with Bonferroni-corrected significance thresholds (meta-analysis p < 5 x 10^-9 for assayed and imputed variants; p < 1 x 10^-6 for non-rare copy number variants). Findings were validated in an independent Finnish dataset (FinnGen, n=135,500). LD Score regression intercepts between 0.999 and 1.137 across all 35 biomarkers indicate well-controlled population stratification. The specific effect size and replication status for rs10935179 are not reproduced in the provided study excerpt.

Lifestyle considerations No lifestyle considerations on file for this variant.