rs10924245 (KIF26B): Schizophrenia Symptom Variant
Key takeaways
- rs10924245 lies near KIF26B, a gene involved in nervous system development
- No genome-wide significant association was found for this variant in schizophrenia symptom analysis
- Top SNPs in this study clustered near neurodevelopment and neuroprotection genes
- Polygenic effects on negative and disorganized schizophrenia symptoms replicated across 16 independent cohorts
- Evidence for this specific variant is preliminary and below genome-wide significance thresholds
Key takeaways
- rs10924245 lies near KIF26B, a gene involved in nervous system development
- No genome-wide significant association was found for this variant in a schizophrenia symptom dimension study
- Top candidate SNPs in this study clustered near genes for neurodevelopment and neuroprotection
- A polygenic effect on negative and disorganized schizophrenia symptoms replicated across 16 independent cohorts
- Evidence for this specific variant remains preliminary and sub-threshold for genome-wide significance
What the research says rs10924245, located near the KIF26B gene (kinesin family member 26B, a protein involved in nervous system development), was examined in a genome-wide association study (GWAS) of clinical symptom dimensions in schizophrenia among 2,454 individuals of European ancestry scored on three factors: positive, negative/disorganized, and mood. No individual SNP in the study, including variants at this locus, reached genome-wide significance across 696,491 tested SNPs, though the variants showing the strongest associations were concentrated in or near genes involved in neurodevelopment, neuroprotection, or neurotransmission, including genes implicated in Mendelian central nervous system disorders. Polygenic score analyses using data from 16 independent Psychiatric GWAS Consortium (PGC) replication samples found that scores derived from the negative/disorganized symptom factor significantly distinguished schizophrenia cases from controls across those external samples.
Reported associations
- Schizophrenia negative and disorganized symptom dimensions: Examined in a GWAS of 2,454 European-ancestry schizophrenia cases rated on the Lifetime Dimensions of Psychosis Scale; no genome-wide significant single-variant association was detected, but this locus was among variants tested in a study where top hits clustered near neurodevelopment and neurotransmission genes
- Polygenic contribution to disorganized symptoms: Polygenic scores based on the negative/disorganized symptom factor distinguished schizophrenia cases from controls across 16 PGC replication samples, providing cross-sample support for the shared genetic architecture of disorganized symptoms and schizophrenia risk
Evidence quality The single available study analyzed 2,454 schizophrenia cases of European ancestry recruited across 10 university-based sites in the United States and Australia. No SNP reached genome-wide significance (the conventional threshold of approximately p < 5 x 10^-8) in any symptom dimension analysis. The strongest replication evidence was a polygenic signal tied to negative and disorganized symptoms across 16 PGC cohorts, but this is a composite result rather than a single-variant finding specific to rs10924245. No direct independent replication of this variant as an individual signal is reported in the provided literature, and its evidence must be considered exploratory and preliminary.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is the KIF26B gene?
KIF26B (kinesin family member 26B) is a gene involved in nervous system development. Kinesin proteins help transport molecules within nerve cells, and this gene has been studied in the context of neurodevelopmental processes.
Is rs10924245 linked to schizophrenia?
rs10924245, located near KIF26B, was examined in a genome-wide association study of schizophrenia symptom dimensions but did not reach genome-wide statistical significance as an individual variant. The current evidence is preliminary.
What does rs10924245 affect?
Based on available research, rs10924245 was studied in the context of schizophrenia clinical symptom dimensions, including positive, negative/disorganized, and mood factors. No significant single-variant effect was detected in the studied population.
What is a genome-wide association study (GWAS)?
A GWAS scans hundreds of thousands of genetic variants across the entire genome to find statistical links with a trait or disease. The study examining rs10924245 used this approach with 2,454 schizophrenia patients to look for variants tied to symptom severity dimensions.
What are negative and disorganized symptoms of schizophrenia?
Negative symptoms refer to reductions in normal behaviors and emotions such as motivation and emotional expression. Disorganized symptoms involve disruptions in thinking and behavior. These are considered core features of chronic schizophrenia and were the dimension most strongly linked to polygenic scores in the available study.