rs10920621 (FMOD-LARP7P1): UK Biobank GWAS signal

Key takeaways

• rs10920621 is located near the FMOD-LARP7P1 locus and was identified as a genome-wide significant association signal in a large UK Biobank genome-wide association study (GWAS).
• The analysis covered approximately 405,000 participants and 13.3 million genetic variants across 79 quantitative and 50 binary traits.
• The Quickdraws statistical method used in the study identified more associations than standard GWAS approaches by modeling non-polygenic (unequally distributed) genetic architectures.
• The specific trait this variant is linked to is not detailed in the available study evidence.

What the research says rs10920621 in the FMOD-LARP7P1 region was identified as a genome-wide association signal in a large-scale analysis of approximately 405,000 UK Biobank participants using a method called Quickdraws, which applies a spike-and-slab prior (a mathematical model that allows for a mix of variants with zero and nonzero effects, rather than assuming all variants contribute equally) combined with stochastic variational inference. Analyzed across 79 quantitative and 50 binary traits and 13.3 million variants, Quickdraws identified 4.97% more quantitative trait associations and 3.25% more binary trait associations than a leading existing GWAS tool called REGENIE on the same dataset. The specific phenotype associated with this locus is not named in the available excerpt of the source study.

Reported associations

• UK Biobank GWAS signal: rs10920621 in the FMOD-LARP7P1 locus was detected as a statistically significant association signal in a study of approximately 405,000 UK Biobank participants spanning 79 quantitative and 50 binary traits; the specific associated trait is not identified in the available study text.

Evidence quality This variant was surfaced using the Quickdraws method applied to 405,088 UK Biobank participants and 13.3 million genetic variants. Quickdraws demonstrates statistical power comparable to the BOLT-LMM algorithm for quantitative traits and exceeds the power of SAIGE, REGENIE, and FastGWA-GLMM for binary traits. The study notes replication of a broader set of association signals in Biobank Japan and FinnGen external cohorts, but whether this specific locus was among those replicated is not determinable from the available text. No effect size, p-value, or specific trait assignment for rs10920621 is available from the provided study excerpt. The evidence for this specific locus should be considered preliminary and incomplete pending further documentation.

Lifestyle considerations No lifestyle considerations on file for this variant.