rs10916844 - DDOST

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study of longitudinal change in CSF tau among non-demented elderly. - Bratislavske lekarske listy (2024) · Liu Y, Zhang N, Liu S, Zhong X, Wang L · PubMed 39344768

  This study conducted a genome-wide association study (GWAS) on longitudinal CSF t-tau and genotype data from 319 non-Hispanic Caucasians within the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. The aim was to identify genetic determinants influencing the rate of change in CSF t-tau, a key biomarker in AD. The GWAS identified a significant single nucleotide polymorphism (SNP), rs17149074, within the C9orf171 (CFAP77) gene region that showed significant association with changes in CSF t-tau over time. Additionally, five other SNPs-rs10916844, rs10916846, rs9425869, rs3744474, and rs8078303-were found to potentially influence CSF t-tau variability. These findings not only enhance our understanding of t-tau's progression in AD but also suggest that these identified SNPs could s

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