rs10906082 - SEC61A2

Magnitude 2.0 · 1 study on file

Reported associations

• Host Genetic Associations with Salivary Microbiome in Oral Cancer. - Journal of dental research (2022) · Yang SF, Lin CW, Chuang CY, Lee YC, Chung WH, Lai HC, Chang LC, Su SC · PubMed 34875929

  Despite the growing recognition of a host genetic effect on shaping gut microbiota composition, the genetic determinants of oral microbiota remain largely unexplored, especially in the context of oral diseases. Here, we performed a microbiome genome-wide association study in 2 independent cohorts of patients with oral squamous cell carcinoma (OSCC, = 144 and 67) and an additional group of noncancer individuals ( = 104). Besides oral bacterial dysbiosis and signatures observed in OSCC, associations of 3 loci with the abundance of genus-level taxa and 4 loci with β diversity measures were detected ( < 0.05) at the discovery stage. The most significant hit (rs10906082 with the genus = 3.55 × 10 at discovery stage) was replicated in a second OSCC cohort. Moreover, the other 2 taxonomical ass

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