rs10875843 (LALBA - OR11M1P): GWAS Variant
Key takeaways
- Identified in a GWAS of approximately 405,000 UK Biobank participants covering 79 quantitative and 50 binary traits
- Detected using Quickdraws, a method that found 4.97% to 22.71% more associations than comparable GWAS tools in the same dataset
- Located at the LALBA and OR11M1P locus
- The specific trait driving this association is not stated in the available study excerpt
Key takeaways
- Identified in a GWAS of approximately 405,000 UK Biobank participants covering 79 quantitative and 50 binary traits
- Detected using Quickdraws, a mixed-model method that found 4.97% to 22.71% more associations than comparable GWAS tools in the same dataset
- The specific trait or traits driving this signal are not stated in the available study text
- Replication was evaluated at the method level in Biobank Japan and FinnGen, but variant-level replication details for this locus are not provided
- Effect size, p-value, and allele frequency for this variant are not reported in the available excerpt
What the research says rs10875843, at the LALBA - OR11M1P locus, was identified in a genome-wide association analysis applying the Quickdraws method to 405,088 UK Biobank samples across 13.3 million variants and 129 traits (79 quantitative, 50 binary). Quickdraws uses a spike-and-slab prior on variant effects combined with stochastic variational inference, a design reported to increase association power beyond that of standard mixed-model methods such as REGENIE and FastGWA. The available study text does not name the specific phenotype linked to this locus, nor does it report an effect size, allele frequency, or p-value for this variant.
Reported associations
- UK Biobank trait (unspecified): Detected among associations from a GWAS of 79 quantitative and 50 binary traits in approximately 405,000 UK Biobank participants; the specific phenotype associated with this locus is not named in the available excerpt.
Evidence quality The source study analyzed 405,088 UK Biobank individuals and 13.3 million variants, representing a large-scale biobank discovery effort. At the method level, Quickdraws identified 4.97% more quantitative-trait associations and 3.25% more binary-trait associations than REGENIE, with replicated signals evaluated in Biobank Japan and FinnGen. However, the available text provides no variant-level evidence for this locus specifically: no p-value, odds ratio, beta coefficient, allele frequency, or associated trait name is given, making it impossible to assess evidence quality for this particular signal from the available material alone. The study has no PMID listed in the provided metadata.
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What is rs10875843?
rs10875843 is a genetic variant at the LALBA and OR11M1P locus. It was detected in a large genome-wide association study using UK Biobank data from over 400,000 participants.
What trait is rs10875843 associated with?
The study that identified this variant covered 79 quantitative and 50 binary traits, but the available research text does not specify which trait or traits are linked to this locus.
How was rs10875843 discovered?
It was identified using a GWAS method called Quickdraws, which applies a spike-and-slab statistical prior to increase the power to detect genetic associations compared to standard methods. The analysis covered 13.3 million variants in 405,088 UK Biobank individuals.
Has rs10875843 been replicated in other populations?
The Quickdraws study evaluated replication of its findings in Biobank Japan and FinnGen at the overall method level. Variant-specific replication data for this locus are not provided in the available study text.