Expressive

rs10858923 - ATP2B1-AS1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Body surface area is a potential obesity index: Its genetic determination and its causality for later-life diseases. - Obesity (Silver Spring, Md.) (2022) · Yu XH, Cao RR, Yang YQ, Deng FY, Bo L, Lei SF · PubMed 36502284

    This study aimed to identify novel genetic factors that contribute to body surface area (BSA) and explore its relationship with complex traits and diseases. Based on more than 330,000 European individuals in the UK Biobank, the first large-scale genome-wide association study for BSA was performed. Comprehensive genetic analysis and enrichment analysis were then performed to explore the biological function of the identified loci. The genetic correlations and causal associations between BSA and other anthropometry parameters, early growth indices, and later-life diseases, respectively, were assessed by complex genetic approaches. Genome-wide association study analysis identified a total of 456 conditionally independent single-nucleotide polymorphism mapping genes with known functions in the

  • Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 39349817

    ABSTRACT: Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components. We identified 1,307 genetic loci associated with MetS that were enriched primarily in brain tissues. Using transcriptomic data, we identified 11 genes associated strongly with MetS. Our phenome-wide association and Mendelian randomization analyses highlighted associations of MetS with diverse di

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Reduce refined carbohydrates and processed foods Moderate

    Refined carbohydrates worsen insulin resistance and metabolic syndrome components including dyslipidemia and hyperglycemia

    Emphasize whole grains, vegetables, lean proteins; limit sugary beverages and refined foods

Discuss with your doctor

  • Metabolic syndrome risk and management plan Moderate

    ATP2B1-AS1 variant shows significant association with metabolic syndrome in large GWAS (p=2.00e-9, n=1,384,348)

Exercise

  • Regular aerobic and resistance exercise Moderate

    ATP2B1-AS1 variant associated with metabolic syndrome risk; exercise is the primary intervention for metabolic syndrome

    150 min per week moderate aerobic or 75 min vigorous, plus resistance training twice weekly

Screening

  • Annual metabolic and cardiovascular screening Moderate

    ATP2B1-AS1 variant associated with metabolic syndrome including hypertension, dyslipidemia, hyperglycemia, abdominal obesity

    Annual fasting glucose, lipid panel, blood pressure, and waist circumference measurement