rs10822834 (CTNNA3): Research Summary

Key takeaways

• No associations for rs10822834 are reported in the provided research sources.
• The available study examined genetic contributions to academic attainment in adolescents but did not address this specific variant.
• Neither CTNNA3 nor rs10822834 appeared among the significant findings in the supplied research.

What the research says The single study provided for this entry is a genome-wide association study (GWAS - a large scan of the genome looking for common DNA variants linked to a trait) of academic attainment in English, maths, and science among adolescents in the Avon Longitudinal Study of Parents and Children (ALSPAC), with sample sizes of approximately 5,983 to 6,089 participants. That study identified rs952964 as the only genome-wide significant single nucleotide polymorphism (SNP - a one-letter change in the DNA sequence at a specific position in the genome) for science attainment, and did not report any association with rs10822834 or CTNNA3.

Reported associations

• No associations with rs10822834 are reported in the provided studies.

Evidence quality The single provided study is a GWAS with approximately 5,983 to 6,089 participants from ALSPAC, reporting SNP-based heritabilities of 41-53% across English, maths, and science. This study does not examine rs10822834, so no evidence quality assessment is possible for this specific variant from the available sources.

Lifestyle considerations No lifestyle considerations on file for this variant.