rs10763170 - PCDH15

Magnitude 2.8 · 1 study on file

Reported associations

• Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma. - Nature genetics (2015) · Ye Z, Li Z, Wang Y, Mao Y, Shen M, Zhang Q, Li S, Zhou L, Shou X, Chen J, Song Z, Ma Z, Zhang Z, Li Y, Ye H, Huang C, Wang T, He W, Zhang Y, Xie R, Qiao N, Qiu H, Huang S, Wang M, Shen J, Wen Z, Li W, Liu K, Zhou J, Wang L, Ji J, Wang Y, Chen H, Cheng H, Shi Z, Zhu Y, Geng D, Yao Z, Tang W, Lu B, Pan L, Zhang Y, Bao W, Wu J, Zheng K, Shi Y, Zhao Y · PubMed 26029870

  Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs1708

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