Expressive

rs10762058 - CTNNA3

Magnitude 4.5 · 1 study on file

Reported associations

  • Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis. - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2009) · Kim SH, Cho BY, Park CS, Shin ES, Cho EY, Yang EM, Kim CW, Hong CS, Lee JE, Park HS · PubMed 19187332

    Toluene diisocyanate (TDI) is the most important cause of occupational asthma, but the genetic mechanism of TDI-induced asthma is still unknown. The objective of the study was to identify susceptibility alleles associated with the TDI-induced asthma phenotype. We conducted a genome-wide association study in 84 patients with TDI-induced asthma and 263 unexposed healthy normal controls using Affymetrix 500K SNPchip. We also investigated the relationships between genetic polymorphisms and transcript levels in Epstein-Barr virus-transformed lymphoblastoid cell lines from patients with TDI-induced asthma enrolled in this study. Genetic polymorphisms of CTNNA3 (catenin alpha 3, alpha-T catenin) were significantly associated with the TDI-induced asthma phenotype (5.84 x 10(-6) for rs10762058, 1.4

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • TDI occupational exposure risk assessment Moderate

    CTNNA3 rs10762058 GG genotype reduces alpha-T-catenin expression, increasing airway reactivity to TDI, causing occupational asthma

    before or during occupational health evaluation; assess current and planned TDI/isocyanate exposure

Lifestyle

  • toluene diisocyanate (TDI) occupational exposure Moderate

    CTNNA3 rs10762058 GG genotype reduces alpha-T-catenin expression, increasing airway hyperresponsiveness to TDI

    consider alternative occupations if currently exposed to TDI or isocyanates in polyurethane or spray coating work