rs10759180 - LINC01505
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 37669986
ABSTRACT: Most genome-wide association studies (GWAS) for lipid traits focus on the separate analysis of lipid traits. Moreover, there are limited GWASs evaluating the genetic variants associated with multiple lipid traits in African ancestry. To further identify and localize loci with pleiotropic effects on lipid traits, we conducted a genome-wide meta-analysis, multi-trait analysis of GWAS (MTAG), and multi-trait fine-mapping (flashfm) in 125,000 individuals of African ancestry. Our meta-analysis and MTAG identified four and 14 novel loci associated with lipid traits, respectively. flashfm yielded an 18% mean reduction in the 99% credible set size compared to single-trait fine-mapping with JAM. Moreover, we identified more genetic variants with a posterior probability of causality >0.9 w
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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total cholesterol and lipid panel Moderate
LINC01505 G allele associates with elevated total cholesterol across 125,000 individuals
Establish baseline lipid panel; repeat annually or as clinically indicated
Discuss with your doctor
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cholesterol management and cardiovascular risk stratification Moderate
Genetic predisposition to elevated cholesterol requires personalized cardiovascular risk assessment
Discuss optimal cholesterol targets and preventive strategies