Expressive

rs10742277 - WT1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

  • Genome-wide association studies for pelvic organ prolapse in the Japanese population - Unknown journal (n.d.) · Unknown authors · PubMed 39349682

    ABSTRACT: Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29-1.68, P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data and previously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2 locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04-1.08, P = 4.

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • pelvic floor muscle training Moderate

    rs10742277-C increases pelvic organ prolapse risk through altered WT1-AS expression affecting connective tissue integrity; targeted pelvic floor strengthening prevents progression

    Discuss with healthcare provider; consider regular pelvic floor exercises as directed by pelvic floor physical therapist

Lifestyle

  • weight management and obesity prevention Moderate

    WT1 variants increase pelvic organ prolapse risk; obesity independently increases POP risk through elevated intra-abdominal pressure and metabolic stress

    Maintain healthy BMI; discuss weight management strategies with healthcare provider if needed

Screening

  • pelvic organ prolapse screening and early detection Moderate

    rs10742277-C significantly increases pelvic organ prolapse risk (OR=1.48); early detection enables timely intervention to prevent progression

    Discuss pelvic organ prolapse screening with healthcare provider, especially around major pelvic events