rs10508196 - NALF1-IT1, NALF1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. - Genes and immunity (2015) · Anderson D, Holt BJ, Pennell CE, Holt PG, Hart PH, Blackwell JM · PubMed 25208829
This genome-wide association study (GWAS) utilises data from the Western Australian Pregnancy Cohort (Raine) Study for 25-hydroxyvitamin D (25(OH)D) levels measured in blood collected at age 6 years (n=673) and at age 14 years (n=1140). Replication of significantly associated genes from previous GWASs was found for both ages. Genome-wide significant associations were found both at age 6 and 14 with single nucleotide polymorphisms (SNPs) on chromosome 11p15 in PDE3B/CYP2R1 (age 6: rs1007392, P=3.9 × 10(-8); age14: rs11023332, P=2.2 × 10(-10)) and on chromosome 4q13 in GC (age 6: rs17467825, P=4.2 × 10(-9); age14: rs1155563; P=3.9 × 10(-9)). In addition, a novel association was observed at age 6 with SNPs on chromosome 7p15 near NPY (age 6: rs156299, P=1.3 × 10(-6)) that could be of fun
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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vitamin D levels Moderate
Genetic variant associated with lower vitamin D levels
Check annually or upon deficiency symptoms; more frequent if baseline is suboptimal
Lifestyle
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sun exposure Low
Regular sun exposure supports endogenous vitamin D synthesis, offsetting genetic predisposition to lower levels
15-30 minutes midday sunlight exposure most days, or as skin type and geography permit
Supplements
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vitamin D3 supplementation Moderate
Genetic predisposition to lower vitamin D may require supplemental intake for optimal levels
1000-2000 IU daily; titrate based on measured blood levels targeting 30-50 ng/mL