rs10493860 (TGFBR3): IBD Risk Variant

Key takeaways

• rs10493860 lies near TGFBR3 and has been studied in relation to inflammatory bowel disease (IBD).
• A 45,106-case multi-ancestry study found 320 IBD-linked genomic loci (specific positions in the genome associated with the disease), including 81 novel ones, but does not explicitly report findings for this specific variant in the available text.
• Crohn's disease genetic effects differ more across ancestries than ulcerative colitis effects do.
• Some IBD gene variants have effects more than 50% stronger in East Asian than in European populations, highlighting why diverse ancestry research matters.

What the research says A multi-ancestry genome-wide association study (GWAS) of IBD - a chronic gastrointestinal disorder with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC) - aggregated 14,393 East Asian cases, 15,456 East Asian controls, approximately 25,042 non-Finnish European cases, approximately 34,915 non-Finnish European controls, 5,671 Finnish cases, and 303,191 Finnish controls, identifying 80 IBD loci in East Asian individuals alone and 320 across both ancestries, 81 of which are novel and implicate new candidate genes including ADAP1 and GIT2. CD genetic effects proved more ancestry-dependent than those for UC; TNFSF15 showed an odds ratio of approximately 1.75 (95% CI: 1.57-1.91) in East Asian individuals versus approximately 1.15 (95% CI: 1.11-1.17) in European individuals, a greater-than-50% difference in effect magnitude. The variant rs10493860 and the TGFBR3 locus are not explicitly discussed in the provided study text, so no effect size, direction, or replication data for this locus can be drawn from this source.

Reported associations The following reflects the broader IBD findings from the study; no findings specific to rs10493860 are explicitly reported in the provided text.

• Inflammatory bowel disease (CD and UC combined): 80 associated loci in East Asian individuals alone; 320 total in meta-analysis with European data; 81 novel, implicating new candidate genes including ADAP1 and GIT2.
• Crohn's disease: Genetic effects more ancestry-dependent than for UC; TNFSF15 shows an odds ratio of approximately 1.75 (95% CI: 1.57-1.91) in East Asian versus approximately 1.15 (95% CI: 1.11-1.17) in European individuals, a difference the study notes may be driven by clinical heterogeneity or gene-environment interactions.
• Ulcerative colitis: Genetic effects more consistent across East Asian and European ancestries compared to CD.

Evidence quality The underlying study is among the largest IBD genetic analyses reported, with population stratification well controlled as confirmed by genomic inflation factors of 0.99-1.05 and LD score regression intercepts of 1.02-1.06 (both measures indicate results are unlikely to be distorted by ancestry differences among participants). No findings specific to the TGFBR3 locus or rs10493860 appear in the available study text. The source study has no PMID listed in the provided metadata, so inline citation links cannot be included. Evidence quality for this specific variant is therefore unassessable from the provided source, and the general IBD findings described above should not be interpreted as direct evidence for or against an association at this locus.

Lifestyle considerations No lifestyle considerations on file for this variant.