Expressive

rs10491334 - CAMK4

Magnitude 4.5 · 2 studies on file

Reported associations

  • Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. - Rejuvenation research (2011) · Malovini A, Illario M, Iaccarino G, Villa F, Ferrario A, Roncarati R, Anselmi CV, Novelli V, Cipolletta E, Leggiero E, Orro A, Rusciano MR, Milanesi L, Maione AS, Condorelli G, Bellazzi R, Puca AA · PubMed 21612516

    Long-living individuals (LLIs) are used to study exceptional longevity. A number of genetic variants have been found associated in LLIs to date, but further identification of variants would improve knowledge on the mechanisms regulating the rate of aging. Therefore, we performed a genome-wide association study on 410 LLIs and 553 young control individuals with a 317K single-nucleotide polymorphism (SNP) chip to identify novel traits associated with aging. Among the top (p < 1 × 10(-4)) SNPs initially identified, we found rs10491334 (CAMKIV) (odds ratio [OR] = 0.55; 95% confidence interval [CI] 0.42-0.73; p = 2.88 × 10(-5)), a variant previously reported associated with diastolic blood pressure, associated also in a replication set of 116 LLIs and 160 controls (OR =

  • Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness - Unknown journal (n.d.) · Unknown authors · PubMed 17903302

    ABSTRACT: Background About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions. Methods In Framingham Heart Study families, we analyzed genome-wide SNP (Affymetrix 100K GeneChip) associations with systolic (SBP) and diastolic (DBP) BP at a single examination in 1971-1975 (n = 1260), at a recent examination in 1998-2001 (n = 1233), and long-term averaged SBP and DBP from 1971-2001 (n = 1327, mean age 52 years, 54% women) and with arterial stiffness measured by arterial tono

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean or DASH diet Moderate

    rs10491334 is associated with elevated blood pressure and reduced longevity; these diets reduce blood pressure and support longevity

    emphasize vegetables, fruits, whole grains, healthy fats; limit sodium

Exercise

  • regular aerobic exercise Moderate

    rs10491334 carriers have reduced CAMKIV expression and reduced longevity; exercise activates SIRT1 and FOXO3A survival pathways and improves blood pressure

    150 minutes per week moderate-intensity aerobic activity

Screening

  • blood pressure screening Moderate

    rs10491334 is significantly associated with elevated diastolic blood pressure in genome-wide association study

    measure annually, or more frequently if baseline elevated