Expressive

rs10484561 - HLA-DQB1 - MTCO3P1

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 - Unknown journal (n.d.) · Unknown authors · PubMed 20639881

    ABSTRACT: To identify susceptibility loci for non-Hodgkin lymphoma (NHL) subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma (FL) in 1,465 FL cases/6,958 controls at 6p21.32 (rs10484561, rs7755224, r2=1.0; combined p-values=1.12×10-29, 2.00×10-19), providing further support that MHC genetic variation influences FL susceptibility. Confirmatory evidence of a previously reported association was also found between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined p-value=4.24×10-9). FULL TEXT: [INTRO] Non-Hodgkin lymphoma (NHL) is a complex group of B- and T-cell neoplasms with >300,000 new cases diagnosed worldwide each year (http://www-dep.iarc.fr/globocan/database.htm). Family and

  • HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study - Unknown journal (n.d.) · Unknown authors · PubMed 33591409

    ABSTRACT: Background The pathophysiology of Henoch-Schönlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe HSP nephritis. Methods The study included 46 HSP patients, 42 of whom had undergone kidney biopsy. Forty-nine pediatric patients with an inflammatory bowel disease (IBD) served as an autoimmune disease control group while Finnish bone marrow and blood donors represented the general reference population (n = 18,757). GWAS was performed for HSP and IBD samples in a case-control manner against the reference population. The analysis also included imputation of human leukocyte antigen (HLA) alleles. Result

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