rs10453225 (LINC01505): Menarche association
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Key takeaways
- Menarche is slightly advanced for the G allele
- The variant reduces TMEM38B expression in thyroid tissue
- No strong evidence linking this SNP to other traits
Key takeaways
- Menarche is slightly advanced for the G allele [25231870]
- The variant reduces TMEM38B expression in thyroid tissue GTEx Portal
- No strong evidence linking this SNP to other traits
What the research says This variant is associated with Menarche (age at onset) reported effect size 0.09 p=6e-66 in about 182 thousand individuals risk allele G [25231870]. The GTEx context shows reduced TMEM38B expression in thyroid tissue GTEx Portal.
Reported associations
- Menarche (advanced) effect size 0.09 p=6e-66 sample ~182k individuals [25231870]
Evidence quality The GWAS includes about 182 thousand participants and reports a strong association with menarche using the G allele (effect size 0.09, p=6e-66). The GTEx expression data is from 953 donors showing reduced TMEM38B in thyroid (slope -0.10, p=1.2e-4). No other trait associations are reported.
Tissue-specific expression effects
- TMEM38B: reduced expression in thyroid GTEx Portal
No lifestyle considerations on file for this variant.
Frequently asked questions
What does rs10453225 do?
It is associated with slightly advanced menarche and reduces TMEM38B expression in thyroid tissue.
Is this variant linked to other health conditions?
The GWAS only reports a link to menarche; no evidence for other traits.
Can I change my risk?
This SNP does not affect disease severity or treatment options.