Expressive

rs10437804 (FZD10-PIWIL1): Variant Research

Key takeaways

  • rs10437804 is a genetic variant located in the FZD10-PIWIL1 gene region.
  • No trait associations were reported for this variant in the available study.
  • The available study focused on serum metal levels and did not cover this specific SNP.
  • Evidence quality for rs10437804 cannot be assessed from the provided source material.

Key takeaways

  • rs10437804 is a genetic variant (single nucleotide polymorphism, or SNP) located in the FZD10-PIWIL1 gene region.
  • No trait associations were reported for this variant in the available study.
  • The available study focused on serum metal levels in Chinese populations and did not cover this specific SNP.
  • Evidence quality for rs10437804 cannot be assessed from the provided source material.

What the research says The only available study is a genome-wide association study (GWAS) and Mendelian randomization analysis of 21 serum metal levels conducted in 2,488 Chinese individuals, with follow-up causal analyses in approximately 179,000 East Asian and 628,000 European participants. That study identified two variants, rs35691438 and rs671, as significantly associated with serum copper levels, but did not report any findings for rs10437804 in the FZD10-PIWIL1 locus. Without source material specifically covering this variant, no empirical claims about its associations can be made from the available evidence.

Reported associations

  • No associations for rs10437804 were reported in the available study.

Evidence quality The available source (Yang et al., Communications biology, 2022) is a well-designed GWAS and Mendelian randomization study with a discovery cohort of 2,488 Chinese individuals and Mendelian randomization analyses drawing on approximately 179,000 East Asian and 628,000 European participants. While the study design is methodologically robust and covers a broad range of metal-level phenotypes and downstream causal outcomes, it does not report results for rs10437804; therefore, evidence quality for this specific variant cannot be rated from the provided material. No conflicting findings, replication data, or p-values for this variant are available in the provided source.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs10437804?

rs10437804 is a single nucleotide polymorphism (SNP), a type of common genetic variation where a single DNA base differs between individuals, located in the genomic region spanning the FZD10 and PIWIL1 genes.

What health conditions is rs10437804 linked to?

No associations between rs10437804 and specific health conditions were reported in the available study. Research specifically focused on this variant would be needed to characterize any associations.

What genes are near rs10437804?

rs10437804 is located in the genomic region spanning FZD10 and PIWIL1. The available study did not report gene-specific findings for this locus.

Is rs10437804 included in large genetic studies?

The available study is a GWAS of serum metal levels in 2,488 Chinese individuals with follow-up in hundreds of thousands of East Asian and European participants, but it did not report findings for this specific variant.