rs10427139 - GPATCH1

Magnitude 2.8 · 1 study on file

Reported associations

• Characterizing Genetic Susceptibility to Colorectal Cancer in Taiwan Through Genome-Wide Association Study. - Molecular carcinogenesis (2024) · Bau DT, Liu TY, Yang JS, Chen WT, Tsai CW, Chang WS, Ke TW, Liao CC, Chen YC, Chang YT, Tsai FJ · PubMed 39392253

  We conducted the first genome-wide association study (GWAS) of colorectal cancer (CRC) in Taiwan with 5342 cases and 61,015 controls. Ninety-two SNPs in three genomic regions reached genome-wide significance (p < 5 × 10 ). The lead SNPs in these three regions were: rs12778523 (OR = 1.18, 95% CI, 1.15-1.23, p = 4.51 × 10 ), an intergenic SNP between RNA5SP299 and LINC02676 at chromosome 10p14; rs647161 (OR = 1.14, 95% CI, 1.09-1.19, p = 2.21 × 10 ), an intronic SNP in PITX1 at 5q31.1, and rs10427139 (OR = 1.20, 95% CI, 1.14-1.28, p = 3.62 × 10 ), an intronic SNP in GPATCH1 at 19q13.1. We further validated CRC susceptibility SNPs previously identified through GWAS in other populations. A total of 61 CRC susceptibility SNPs were confirmed in Tai

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