rs10416963 (UNC13A): Variant Overview

Key takeaways

• rs10416963 is a single nucleotide polymorphism (SNP) located in the UNC13A gene region
• The only study provided is a genome-wide association study (GWAS) of childhood obesity traits in 815 Hispanic children
• The provided study text does not report a specific association between rs10416963 and any measured trait
• No effect sizes, odds ratios, or p-values specific to this variant are available from the provided materials
• No lifestyle or clinical findings can be derived from the available evidence

What the research says A GWAS of childhood obesity in the Hispanic population genotyped 1.1 million SNPs across 815 children from 263 families, examining traits including anthropometry, body composition, metabolites, hormones, inflammation, diet, energy expenditure, and physical activity. The study identified several genome-wide significant loci including MTNR1B, APOA5/ZNF259, PCSK2, and DARC, but the provided text covers only the introduction and part of the methods and does not report findings specific to rs10416963 or UNC13A.

Reported associations

• Childhood obesity-related traits: The only study provided examined body composition, fasting glucose, triglycerides, total antioxidants, thyroid-stimulating hormone (TSH), immune markers, sleep duration, and energy expenditure in Hispanic children ages 4-19, but no association specific to rs10416963 appears in the available study text.

Evidence quality The sole study provided examined 815 Hispanic children from 263 families using 1.1 million SNP genotyping across a broad range of obesity-related phenotypes. Only the introduction and partial methods section were available; results specific to rs10416963 or UNC13A are absent from the provided text. Without a reported p-value, effect size, sample-level replication, or trait association for this variant, evidence quality cannot be assessed from the provided materials.

Lifestyle considerations No lifestyle considerations on file for this variant.