rs10399884 (THAP3P1 - CDK4P1): Research Overview

Key takeaways

• The studies provided for this entry do not report any genome-wide significant associations for rs10399884.
• No effect sizes, trait associations, or replication data for this variant appear in the supplied evidence.
• No drug response or tissue-specific expression data for this variant are on file.
• This entry will be updated as additional evidence becomes available.

What the research says The single study provided for this entry examined serum metal levels, including copper, in a Chinese cohort of 2,488 individuals and applied Mendelian randomization analyses drawing on approximately 179,000 East Asian and 628,000 European participants. That study identified rs35691438 and rs671 as the two SNPs significantly associated with serum copper levels, but rs10399884 and the THAP3P1 - CDK4P1 locus are not mentioned or analyzed in the provided evidence.

Reported associations

• No associations for rs10399884 were reported in the studies provided for this entry.

Evidence quality The study supplied covers large, multi-ethnic Mendelian randomization analyses focused on serum metal phenotypes and their downstream effects in up to 628,000 European and 179,000 East Asian participants, but does not report findings for rs10399884. No replication data, p-values, or effect sizes for this variant can be drawn from the provided material, and the evidence quality for this variant cannot be assessed from these studies.

Lifestyle considerations No lifestyle considerations on file for this variant.