Expressive

rs1039122 (SLC18A1): Korean Dyslipidaemia GWAS

Key takeaways

  • rs1039122 sits near the RPL30P9 pseudogene and SLC18A1 and was studied in a large Korean dyslipidaemia GWAS
  • The source study enrolled 58,701 Korean adults and assessed how genetic variants and macronutrient intake interact to affect cardiovascular risk
  • Specific effect sizes for rs1039122 are not available in the provided study excerpt
  • The research is based on a Korean-only cohort, which may limit how broadly the findings apply

Key takeaways

  • rs1039122 sits near the RPL30P9 pseudogene and the SLC18A1 (solute carrier family 18, member A1) locus
  • This variant was examined in the context of a large Korean genome-wide association study (GWAS) of dyslipidaemia (abnormal blood lipid levels) and cerebro-cardiovascular disease (CCD)
  • The study enrolled 58,701 Korean adults and investigated how genetic variants interact with dietary protein, carbohydrate, and fat intake to influence cardiovascular risk
  • Specific effect sizes and directional associations for rs1039122 are not present in the available study text

What the research says rs1039122, at the RPL30P9 - SLC18A1 locus, appears in the context of the Korean Genome and Epidemiology Study (KoGES), a cohort of 58,701 Korean adults examined for genetic variants associated with dyslipidaemia and CCD. The study included 20,596 dyslipidaemia cases and 1,027 CCD cases, assessing macronutrient intake via food frequency questionnaire and adjusting for age, sex, BMI, exercise, smoking, and alcohol intake. No PMID was supplied with the source study, and the full results table describing specific associations at this locus is not included in the available study excerpt.

Reported associations

  • Dyslipidaemia and cerebro-cardiovascular disease: This locus was identified in a Korean dyslipidaemia GWAS that also examined CCD outcomes; the direction and magnitude of association specific to rs1039122 are not detailed in the available text

Evidence quality The source study draws on a large Korean population cohort (n=58,701) with a substantial dyslipidaemia case group (n=20,596) and 1,027 CCD cases, providing reasonable statistical power for a GWAS. The study adjusted for major confounders including age, sex, BMI, exercise status, smoking, alcohol intake, and two genetic ancestry principal components. However, the population is exclusively Korean, which may limit generalizability to other ancestry groups. No PMID is available for this study from the provided metadata, and the complete results for rs1039122 are absent from the available text excerpt. As a result, the evidence quality for this specific variant cannot be fully characterized from the materials provided.

Lifestyle considerations No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • HDL cholesterol levels Moderate

    This variant is associated with HDL cholesterol variation in a large GWAS cohort study.

    Annual lipid panel measurement

Frequently asked questions

What is rs1039122?

rs1039122 is a genetic variant near the RPL30P9 pseudogene and the SLC18A1 gene. It appears in a Korean genome-wide study of dyslipidaemia (abnormal blood lipid levels) and cerebro-cardiovascular disease.

What is the SLC18A1 gene?

SLC18A1 (solute carrier family 18, member A1) is a gene near the rs1039122 variant. In the context of the available research, it was part of a genomic region studied in a large Korean cohort examining genetic contributors to dyslipidaemia and cardiovascular risk.

Is rs1039122 linked to heart disease?

rs1039122 appears in a Korean GWAS that studied dyslipidaemia-related genetic variants and cardiovascular disease. Specific directional associations and effect sizes for this variant are not described in the available study excerpt.

What population was rs1039122 studied in?

The available research on this variant comes from the Korean Genome and Epidemiology Study (KoGES), a cohort of 58,701 Korean adults. The findings may not generalize to people of other ancestries.

What is RPL30P9?

RPL30P9 is a pseudogene located near rs1039122. Both it and the nearby SLC18A1 gene are part of the genomic region studied in a Korean GWAS investigating genetic links to abnormal blood lipid levels and cardiovascular disease.