rs1039002 - PDE10A

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-Wide Association Study in Bipolar Patients Stratified by Co-Morbidity - Unknown journal (n.d.) · Unknown authors · PubMed 22205951

  ABSTRACT: Background Bipolar disorder is a severe psychiatric disorder with high heritability. Co-morbid conditions are common and might define latent subgroups of patients that are more homogeneous with respect to genetic risk factors. Methodology In the Caucasian GAIN bipolar disorder sample of 1000 cases and 1034 controls, we tested the association of single nucleotide polymorphisms with patient subgroups defined by co-morbidity. Results Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10−8). PDE10A has been implicated in the pathophysiology of psychosis. Antagonists to the encoded protein are currently in

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