JAZF1 rs10254284: increased expression in brain and artery
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Key takeaways
- Increased JAZF1 expression in brain and artery
- Higher expression also seen in thyroid
- No known health risk linked to this variant
Key takeaways Increased JAZF1 expression in brain and artery, higher expression also seen in thyroid, no known health risk linked to this variant.
What the research says The GWAS of 3710 SLE patients and controls identified several known loci including IRF5-TNPO3 HLA DQA2-DQB1 ITGAM STAT4 TNIP1 NCF2 IRAK1 and a novel locus on 10q24.33 rs4917385 with an eQTL effect at USMG5/miR1307 [PMID 26606652].
Reported associations The supplied studies do not report a direct trait association for this variant; the rsid appears via [study context].
Evidence quality The GWAS used 3710 SLE patients and healthy controls with sample sizes large enough to detect modest effects. The novel locus rs4917385 shows an eQTL effect at USMG5/miR1307. The supplied studies do not report a direct trait association for this variant; the rsid appears via [study context].
Tissue-specific expression effects
- JAZF1: increased expression whole blood, aorta, and thyroid GTEx Portal
Lifestyle considerations No lifestyle considerations on file for this variant.
Frequently asked questions
What does the JAZF1 gene do?
JAZF1 is a transcription factor that regulates gene expression in multiple tissues.
Is rs10254284 linked to disease?
The variant is associated with higher expression but no known health risk has been reported.
Can I test for this variant?
You can order a DNA analysis that includes the rs10254284 SNP if you have a raw file.