Expressive

rs10223797 (NT5DC1): UK Biobank GWAS variant

Key takeaways

  • rs10223797 is near the NT5DC1 gene and was identified in a UK Biobank GWAS of approximately 405,000 individuals
  • The study used Quickdraws, a new method that found roughly 5% more quantitative trait associations than standard approaches
  • No specific trait or effect size for this variant is reported in the available source material
  • Evidence is very preliminary with only one methods-focused paper provided and no variant-level results in the available excerpt

Key takeaways

  • rs10223797 is located near the NT5DC1 gene and was identified in a large-scale UK Biobank genome-wide association study covering approximately 405,000 individuals
  • The study used Quickdraws, a new GWAS method that identified roughly 5% more quantitative trait associations and 3% more binary trait associations than the widely used REGENIE method
  • No specific trait or effect size for this variant is reported in the available source material
  • Evidence for this variant is very preliminary; the sole provided source is a methods paper whose variant-level results are not included in the available excerpt
  • No lifestyle, pharmacogenomic, or tissue-expression data are available for this variant from the provided sources

What the research says A genome-wide association study (a large statistical scan of the genome linking DNA variants to traits) applied the Quickdraws algorithm to approximately 405,000 UK Biobank participants, analyzing 13.3 million variants across 79 quantitative and 50 binary (disease) traits. The study reported that Quickdraws identified 4.97% more quantitative trait associations and 3.25% more binary trait associations than REGENIE on the same dataset, with comparable computational cost. The specific traits or effect sizes associated with rs10223797 are not stated in the provided study text.

Reported associations

  • UK Biobank complex traits (quantitative and binary): rs10223797 appears in the context of a GWAS spanning 79 quantitative and 50 binary traits in approximately 405,000 UK Biobank individuals; the specific trait linked to this locus is not described in the available study excerpt

Evidence quality The sole provided source is a methods paper (Loya H, Kalantzis G, Cooper F, Palamara PF, Nature Genetics, 2025) introducing the Quickdraws algorithm, applied to approximately 405,000 UK Biobank individuals. No variant-level association data, effect sizes, p-values, or trait labels for rs10223797 are present in the provided text. No PMID is listed in the study metadata. No replication data from external cohorts such as Biobank Japan or FinnGen are described for this specific variant, although the paper reports general replication of Quickdraws findings in those cohorts. The available evidence for this locus should be considered very preliminary and incomplete based on the material provided.

Lifestyle considerations No lifestyle considerations on file for this variant.

Frequently asked questions

What is rs10223797?

rs10223797 is a genetic variant located near the NT5DC1 gene. It was identified in a large genome-wide association study using UK Biobank data from approximately 405,000 participants, though the specific trait it is associated with is not detailed in currently available sources.

What does the NT5DC1 gene do?

The available study does not describe the biological function of NT5DC1. The study that surfaced this variant focused on introducing a new GWAS analysis method rather than characterizing the gene's role.

What traits is rs10223797 linked to?

Based on the available study material, the specific trait associated with rs10223797 is not stated. The study covered 79 quantitative and 50 binary traits in UK Biobank, but variant-level results are not included in the provided text.

Is rs10223797 related to any diseases?

The available source material does not specify whether rs10223797 is linked to any particular disease. No disease associations or effect sizes are reported for this variant in the provided study excerpt.