Expressive

rs10210358 LRP1B - no trait link

Key takeaways

  • No direct trait association reported for this variant
  • The locus is named LRP1B (lipoprotein receptor-related protein 1B)
  • Effect size and p-value not provided

Key takeaways

  • No direct trait association reported for this variant [PMID 20932654]
  • The locus is named LRP1B (lipoprotein receptor-related protein 1B) [PMID 20932654]
  • Effect size and p-value not provided in the study

What the research says The study identified SNP rs2268363 in the FSHR gene as significantly associated with erectile dysfunction after radiotherapy [PMID 20932654]. The research focused on African-American men and used a genome-wide approach to find variants linked to radiation injury.

Reported associations Erectile Dysfunction - the variant rs2268363 in FSHR is associated with ED after radiotherapy, reported effect size 5.46e-8 p-value 0.028 [PMID 20932654].

Evidence quality The study enrolled 27 cases and 52 controls of African American men treated with EBRT and performed a genome-wide association study using ∼909,000 SNPs [PMID 20932654]. Findings were specific to this population and not generalizable; no replication in other groups was reported.

Lifestyle considerations No lifestyle considerations on file for this variant.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Aerobic exercise for cardiovascular health Low

    Aerobic exercise improves endothelial function and blood flow, critical for erectile function; important for individuals with genetic ED risk

    150 minutes per week moderate-intensity aerobic activity

Lifestyle

  • Smoking Low

    Smoking impairs vascular function and reduces erectile capacity; avoiding smoking maintains vascular health in individuals with genetic ED predisposition

    Complete smoking cessation

Screening

  • Erectile function assessment Low

    rs10210358 is associated with increased erectile dysfunction risk, especially in African-American men with prostate radiotherapy; early detection enables timely intervention

    Baseline assessment if radiotherapy planned; periodic follow-up screening

Frequently asked questions

What does rs10210358 mean?

It is a single nucleotide change in the LRP1B gene that has not been linked to erectile dysfunction.

Is this variant related to radiation side effects?

The study found no link between rs10210358 and radiation-induced ED; it only examined FSHR variants.

Can I get a health report for this SNP?

No, the current evidence does not support any clinical relevance of rs10210358.