Expressive

rs10210358 - LRP1B

Magnitude 4.5 · 2 studies on file

Reported associations

  • Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 32450446

    ABSTRACT: Genome-wide association studies have identified many loci associated with Alzheimer's dementia. However, these variants only explain part of the heritability of Alzheimer's disease (AD). As genetic epistasis can be a major contributor to the "missing heritability" of AD, we conducted genome-wide epistasis screening for AD pathologies in two independent cohorts. First, we performed a genome-wide epistasis study of AD-related brain pathologies (Nmax = 1,318) in ROS/MAP. Candidate interactions were validated using cerebrospinal fluid biomarkers of AD in ADNI (Nmax = 1,128). Further functional analysis tested the association of candidate interactions with neuroimaging phenotypes. For tau and amyloid-β (Aβ) pathology, we identified 2,803 and 464 candidate SNP-SNP interaction

  • Genome Wide Association Study to Identify Single Nucleotide Polymorphisms (SNPs) Associated with the Development of Erectile Dysfunction in African-American Men Following Radiotherapy for Prostate Cancer - Unknown journal (n.d.) · Unknown authors · PubMed 20932654

    ABSTRACT: Purpose To identify single nucleotide polymorphisms (SNPs) associated with erectile dysfunction (ED) among African American prostate cancer patients treated with external beam radiation therapy (EBRT). Methods and Materials A cohort of African American prostate cancer patients treated with EBRT was followed for development of ED using the five-item Sexual Health Inventory for Men (SHIM) questionnaire. Final analysis included 27 cases (post-treatment SHIM score ≤ 7) and 52 controls (post-treatment SHIM score ≥ 16). A genome-wide association study was performed using ∼909,000 SNPs genotyped on Affymetrix 6.0 arrays. Results We identified SNP rs2268363, located in the follicle stimulating hormone receptor (FSHR) gene, as significantly associated with ED after correcting for mu

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Aerobic exercise for cardiovascular health Low

    Aerobic exercise improves endothelial function and blood flow, critical for erectile function; important for individuals with genetic ED risk

    150 minutes per week moderate-intensity aerobic activity

Lifestyle

  • Smoking Low

    Smoking impairs vascular function and reduces erectile capacity; avoiding smoking maintains vascular health in individuals with genetic ED predisposition

    Complete smoking cessation

Screening

  • Erectile function assessment Low

    rs10210358 is associated with increased erectile dysfunction risk, especially in African-American men with prostate radiotherapy; early detection enables timely intervention

    Baseline assessment if radiotherapy planned; periodic follow-up screening