rs10191329 - ZNF638 - DYSF

Magnitude 2.2 · 1 study on file

Reported associations

• Novel genetic locus and CNS resilience modulate multiple sclerosis severity - Unknown journal (n.d.) · Unknown authors · PubMed 37380766

  ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that results in significant neurodegeneration in the majority of those affected and is a common cause of chronic neurological disability in young adults. To provide insight into the mechanisms determining progression, we conducted a genome-wide association study of the age-related MS severity score in 12,584 cases and replicated our findings in a further 9,805 cases. We identified a significant association with rs10191329 in the DYSF-ZNF638 locus (P=3.6×10−9), the risk allele shortening the median time to require a walking aid by up to 3.7 years and increasing brainstem and cortical pathology in brain tissue. We also identified suggestive association with rs149097173 in the DNM3-PIGC locus (P=

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