rs10176318 - TEX41

Magnitude 2.2 · 1 study on file

Reported associations

• Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 31407531

  ABSTRACT: Abstract Background Left ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography. Methods We evaluated the main effects of the three most common antihypertensive treatments for AAs as well as the single nucleotide polymorphism (SNP)‐by‐drug interaction on LVM and relative wall thickness (RWT) in 2,068 participants across five community‐based cohorts. Treatments included thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACE‐Is), and dihydropyridine

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